The emerging role of mass spectrometry-based proteomics in drug discovery
Proteins are the main targets of most drugs; however, system-wide methods to monitor
protein activity and function are still underused in drug discovery. Novel biochemical …
protein activity and function are still underused in drug discovery. Novel biochemical …
Chemoproteomic approaches to drug target identification and drug profiling
M Bantscheff, G Drewes - Bioorganic & medicinal chemistry, 2012 - Elsevier
Chemoproteomics represents a new research discipline at the interface of medicinal
chemistry, biochemistry, and cell biology focused on studying the molecular mechanisms of …
chemistry, biochemistry, and cell biology focused on studying the molecular mechanisms of …
Revealing promiscuous drug–target interactions by chemical proteomics
The (poly-) pharmacological activities of a drug can only be understood if its interactions with
cellular components are comprehensively characterized. Mass spectrometry-based …
cellular components are comprehensively characterized. Mass spectrometry-based …
Mass spectrometry-based proteomics in preclinical drug discovery
Preclinical stages in the drug discovery process require a multitude of biochemical and
genetic assays in order to characterize the effects of drug candidates on cellular systems …
genetic assays in order to characterize the effects of drug candidates on cellular systems …
How chemoproteomics can enable drug discovery and development
RE Moellering, BF Cravatt - Chemistry & biology, 2012 - cell.com
Creating first-in-class medications to treat human disease is an extremely challenging
endeavor. While genome sequencing and genetics are making direct connections between …
endeavor. While genome sequencing and genetics are making direct connections between …
Proteomics in drug development: the dawn of a new era?
M Frantzi, A Latosinska… - PROTEOMICS–Clinical …, 2019 - Wiley Online Library
Mass spectrometry offers the potential of acquiring high resolution data depicting the
functional status of a group of healthy or diseased individuals, according to different …
functional status of a group of healthy or diseased individuals, according to different …
The role of mass spectrometry in biomarker discovery and measurement
BL Ackermann, JE Hale, KL Duffin - Current drug metabolism, 2006 - ingentaconnect.com
Recent advances in the biological and analytical sciences have led to unprecedented
interest in the discoveryand quantitation of endogenous molecules that serve as indicators …
interest in the discoveryand quantitation of endogenous molecules that serve as indicators …
Emerging mass spectrometry-based proteomics methodologies for novel biomedical applications
LK Pino, J Rose, A O'Broin, S Shah… - Biochemical Society …, 2020 - portlandpress.com
Research into the basic biology of human health and disease, as well as translational
human research and clinical applications, all benefit from the growing accessibility and …
human research and clinical applications, all benefit from the growing accessibility and …
Proteomics: a major new technology for the drug discovery process
MJ Page, B Amess, C Rohlff, C Stubberfield… - Drug discovery today, 1999 - Elsevier
Proteomics is a new enabling technology that is being integrated into the drug discovery
process. This will facilitate the systematic analysis of proteins across any biological system …
process. This will facilitate the systematic analysis of proteins across any biological system …
Reimagining druggability using chemoproteomic platforms
JN Spradlin, E Zhang, DK Nomura - Accounts of Chemical …, 2021 - ACS Publications
Conspectus One of the biggest bottlenecks in modern drug discovery efforts is in tackling the
undruggable proteome. Currently, over 85% of the proteome is still considered undruggable …
undruggable proteome. Currently, over 85% of the proteome is still considered undruggable …