The interaction between the vascular endothelium and hemodynamic forces (and more
specifically, fluid shear stress), induced by the flow of blood, plays a major role in vascular …

The receptor tyrosine kinase (RTK) Tie2 is expressed predominantly on endothelial cells.
Tie2 is critical for vasculogenesis during development and could be important for …

The receptor tyrosine kinase tie-1 is essential for angiogenesis where it appears to have a
role in vessel maturation. Here we have examined the effects of hypoxia and vascular …

Although the response of endothelial cells to the disturbed blood flow in the vicinity of
atherosclerotic lesions is known to be distinct from that elicited by nonatherogenic laminar …

Atherosclerotic plaques develop in a nonrandom manner along the vasculature following a
hemodynamically determined distribution profile. The pathogenesis of shear stress–induced …

TIE1, an endothelial-cell-specific tyrosine kinase receptor, is required for the survival and
growth of microvascular endothelial cells during the capillary sprouting phase of vascular …

Tie1 is an endothelial receptor tyrosine kinase essential for development and maintenance
of the vascular system. Here we report generation of transgenic mice expressing enhanced …

The receptor tyrosine kinase Tie-1 is expressed predominantly in endothelial cells where it
physically associates with the related receptor Tie-2. Positive signalling through Tie-2 is …

The orphan receptor tyrosine kinase Tie-1 is expressed in endothelial cells and is essential
for vascular development. Nothing is known about the signaling pathways utilized by this …

The Tie-2 receptor plays a key role in vascular development, although little is known about
the factors controlling its expression. Here we report the first cloning and characterisation of …