Neoplastic cells are characterized by distinct alterations in the genome that are associated
with characteristic changes in cell physiology: self-sufficiency in growth signals, insensitivity …

Vascular Endothelial Growth Factor (VEGF) is an endothelial cell-specific mitogen in vitro
and an angiogenic inducer in a variety of in vivo models. The tyrosine kinases Flt-1 and KDR …

The establishment of a vascular supply is one of the earliest and most important events
occurring during embryonic development. Growth and maturation of a functional vascular …

Angiogenesis is an important component in the progression and metastasis of solid tumors.
We now appreciate that angiogenesis is also critically involved in the pathogenesis of …

The field of angiogenesis received a huge boost in 2003 with the announcement of positive
results in a phase III clinical trial using a vascular endothelial growth factor (VEGF)-blocking …

Angiogenesis is important in a variety of physiologic and pathologic disorders. It is a central
element in embryogenesis, ovulation, wound healing, diabetic retinopathy, and rheumatoid …

Growth of new blood vessels, ie angiogenesis, is a fundamental process during
embryogenesis and in some specific periods of adult life (reproductive cycle, wound …

Endothelial cell signal transduction mechanisms involved in angiogenesis have come into
focus in cancer research when it was realized that solid tumors are dependent on …

The development of a number of novel tumor therapies targeting the function of vascular
endothelial growth factors (VEGFs) and their receptors has promoted an interest in …

New blood vessel formation (angiogenesis) is a fundamental event in the process of tumor
growth and metastatic dissemination. Hence, the molecular basis of tumor angiogenesis has …