Insights from the first putative biosynthetic gene cluster for a lichen depside and depsidone

D Armaleo, X Sun, C Culberson - Mycologia, 2011 - Taylor & Francis
The genes for polyketide synthases (PKSs), enzymes that assemble the carbon backbones
of many secondary metabolites, often cluster with other secondary pathway genes. We …

Cloning and sequence characterization of a non-reducing polyketide synthase gene from the lichen Xanthoparmelia semiviridis

YH Chooi, DM Stalker, MA Davis, I Fujii, JA Elix… - Mycological …, 2008 - Elsevier
Lichens produce a diverse array of secondary metabolites that have shown various
biological activities. Of particular interest are the coupled phenolics that originate from …

Linking a gene cluster to atranorin, a major cortical substance of lichens, through genetic dereplication and heterologous expression

W Kim, R Liu, S Woo, KB Kang, H Park, YH Yu, HH Ha… - MBio, 2021 - Am Soc Microbiol
The depside and depsidone series compounds of polyketide origin accumulate in the
cortical or medullary layers of lichen thalli. Despite the taxonomic and ecological …

Characterization of a non-reducing polyketide synthase gene from lichen Dirinaria applanata

R Valarmathi, GN Hariharan, G Venkataraman… - Phytochemistry, 2009 - Elsevier
Lichens are known to produce a variety of secondary metabolites including polyketides that
have diverse biological role (s). The biosynthesis of fungal polyketides is governed by type I …

Cloning and heterologous transcription of a polyketide synthase gene from the lichen Solorina crocea

AN Gagunashvili, SP Davíðsson, ZO Jónsson… - Mycological …, 2009 - Elsevier
Lichens and most ascomycete fungi produce polyketide secondary metabolites often with
valuable biological activities. Their biosynthesis is primarily governed by large iterative …

[HTML][HTML] Identification of a lichen depside polyketide synthase gene by heterologous expression in Saccharomyces cerevisiae

JT Kealey, JP Craig, PJ Barr - Metabolic Engineering Communications, 2021 - Elsevier
Lichen-forming fungi produce a variety of secondary metabolites including bioactive
polyketides. Advances in DNA and RNA sequencing have led to a growing database of new …

High Diversity of Type I Polyketide Genes in Bacidia rubella as Revealed by the Comparative Analysis of 23 Lichen Genomes

JV Gerasimova, A Beck, S Werth, P Resl - Journal of Fungi, 2022 - mdpi.com
Fungi involved in lichen symbioses produce a large array of secondary metabolites that are
often diagnostic in the taxonomic delimitation of lichens. The most common lichen …

Lost in translation: challenges with heterologous expression of lichen polyketide synthases

RL Bertrand, JL Sorensen - ChemistrySelect, 2019 - Wiley Online Library
The ability to functionally express proteins in hosts is a precondition to an advanced
understanding of the biosynthetic pathways that are responsible for producing life's complex …

A transcribed polyketide synthase gene from Xanthoria elegans

G Brunauer, L Muggia, E Stocker-Wörgötter… - Mycological …, 2009 - Elsevier
We characterize the transcript of a polyketide synthase gene (PKS) from the cultured
mycobiont of Xanthoria elegans (XePKS1) using SMART-rapid amplification of cDNA ends …

Algal carbohydrates affect polyketide synthesis of the lichen-forming fungus Cladonia rangiferina

ME Elshobary, ME Osman, AM Abo-Shady, E Komatsu… - Mycologia, 2016 - Taylor & Francis
Lichen secondary metabolites (polyketides) are produced by the fungal partner, but the role
of algal carbohydrates in polyketide biosynthesis is not clear. This study examined whether …