Compartmentalization and molecular traffic in secondary metabolism: a new understanding of established cellular processes
Great progress has been made in understanding the regulation of expression of genes
involved in secondary metabolism. Less is known about the mechanisms that govern the …
involved in secondary metabolism. Less is known about the mechanisms that govern the …
A key role for vesicles in fungal secondary metabolism
A Chanda, LV Roze, S Kang… - Proceedings of the …, 2009 - National Acad Sciences
Eukaryotes have evolved highly conserved vesicle transport machinery to deliver proteins to
the vacuole. In this study we show that the filamentous fungus Aspergillus parasiticus …
the vacuole. In this study we show that the filamentous fungus Aspergillus parasiticus …
A possible role for exocytosis in aflatoxin export in Aspergillus parasiticus
Filamentous fungi synthesize bioactive secondary metabolites with major human health and
economic impacts. Little is known about the mechanisms that mediate the export of these …
economic impacts. Little is known about the mechanisms that mediate the export of these …
Cellular compartmentalization of secondary metabolism
HC Kistler, K Broz - Frontiers in microbiology, 2015 - frontiersin.org
Fungal secondary metabolism is often considered apart from the essential housekeeping
functions of the cell. However, there are clear links between fundamental cellular …
functions of the cell. However, there are clear links between fundamental cellular …
Molecular mechanisms of Aspergillus flavus secondary metabolism and development
The plant and human opportunistic fungus Aspergillus flavus is recognized for the
production of the carcinogen aflatoxin. Although many reviews focus on the wealth of …
production of the carcinogen aflatoxin. Although many reviews focus on the wealth of …
Aflatoxin biosynthesis is a novel source of reactive oxygen species—a potential redox signal to initiate resistance to oxidative stress?
LV Roze, M Laivenieks, SY Hong, J Wee, SS Wong… - Toxins, 2015 - mdpi.com
Aflatoxin biosynthesis in the filamentous fungus Aspergillus parasiticus involves a minimum
of 21 enzymes, encoded by genes located in a 70 kb gene cluster. For aflatoxin biosynthesis …
of 21 enzymes, encoded by genes located in a 70 kb gene cluster. For aflatoxin biosynthesis …
An LaeA-and BrlA-dependent cellular network governs tissue-specific secondary metabolism in the human pathogen Aspergillus fumigatus
Biosynthesis of many ecologically important secondary metabolites (SMs) in filamentous
fungi is controlled by several global transcriptional regulators, like the chromatin modifier …
fungi is controlled by several global transcriptional regulators, like the chromatin modifier …
Unlocking the Secrets Behind Secondary Metabolism: A Review of Aspergillus flavus from Pathogenicity to Functional Genomics
KA Scheidegger, GA Payne - Journal of Toxicology: Toxin Reviews, 2003 - Taylor & Francis
Aspergillus flavus has received a considerable amount of attention due to its ability to
produce aflatoxin, a secondary metabolite that is both immunosuppressive and carcinogenic …
produce aflatoxin, a secondary metabolite that is both immunosuppressive and carcinogenic …
Regulation of secondary metabolism in filamentous fungi
Fungal secondary metabolites are of intense interest to humankind due to their
pharmaceutical (antibiotics) and/or toxic (mycotoxins) properties. In the past decade …
pharmaceutical (antibiotics) and/or toxic (mycotoxins) properties. In the past decade …
Revitalization of a Forward Genetic Screen Identifies Three New Regulators of Fungal Secondary Metabolism in the Genus Aspergillus
The study of aflatoxin in Aspergillus spp. has garnered the attention of many researchers
due to aflatoxin's carcinogenic properties and frequency as a food and feed contaminant …
due to aflatoxin's carcinogenic properties and frequency as a food and feed contaminant …