Treponema pallidum subsp. pallidum is a fastidious spirochete and the etiologic agent of
syphilis, a sexually transmitted infection (STI). Syphilis diagnoses and disease staging are …

The diagnosis of syphilis can be complicated when it is based on diverse clinical
manifestations, dark-field microscopy, and serology. In the present study, therefore, we …

Syphilis, caused by the spirochete Treponema pallidum subspecies pallidum, is a rising
global public health concern and laboratory diagnostics remain challenging. Especially …

Background Syphilis is a growing public health problem among men who have sex with men
(MSM) globally. Rapid and accurate detection of syphilis is vital to ensure patients and their …

Background Syphilis is a sexually transmitted infection caused by Treponema pallidum,
subspecies pallidum. As these bacteria are difficult to culture, syphilis must be diagnosed by …

There has been a resurgence of syphilis diagnoses in Australia. We investigated whether
our Treponema pallidum PCR test provides any additional diagnostic information over …

Background Serology is negative in a proportion of primary syphilis cases where
Treponema pallidum PCR testing is positive. We aimed to identify discordant, T. pallidum …

Background Syphilis diagnosis relies on serological tests, which may be falsely nonreactive
or may be reactive but not reflect current syphilis. Methods Polymerase chain reaction for …

Background Syphilis remains a major challenge and a complex diagnosis. We aim to
evaluate the role of polymerase chain reaction (PCR) in Treponema pallidum (Tp) detection …

Background Early diagnosis of Treponema pallidum infection is helpful for disease
management, and conventional PCR is suitable for lesion swabs of patients with probable …