Background Syphilis is a complex, multistage, sexually transmitted infection (STI) caused by
the bacterium Treponema pallidum subspecies pallidum (TP). New diagnostic tools are …

Background Syphilis diagnosis may be challenging, especially in the asymptomatic and
early clinical stages. We evaluated the presence of Treponema pallidum DNA (TP-DNA) in …

Objectives We evaluated a real-time quantitative PCR (qPCR) for detection of the
Treponema pallidum (TP) genome in clinical samples through simultaneous detection of two …

Background Syphilis transmission is increasing, and precisely how Treponema pallidum is
transmitted sexually from person to person is unclear. We aimed to determine the frequency …

Background Early diagnosis of Treponema pallidum infection is helpful for disease
management, and conventional PCR is suitable for lesion swabs of patients with probable …

Syphilis, caused by Treponema pallidum subspecies pallidum (TP), is a complex multistage
infectious disease. Systematic dissemination occurs within a few hours of transmission. We …

Background Syphilis is a growing public health problem among men who have sex with men
(MSM) globally. Rapid and accurate detection of syphilis is vital to ensure patients and their …

Syphilis rates in much of the world are now at their highest levels in almost three decades,
and new approaches to controlling syphilis, including diagnostic tests with shorter window …

Early detection and treatment of syphilis will reduce the infectious period and transmission.
We aimed to determine whether screening men who have sex with men (MSM) taking HIV …

Background Treponemal immunoassays are increasingly used for syphilis screening with
the reverse sequence algorithm. There are few data describing performance of treponemal …