Computational pharmaceutics-A new paradigm of drug delivery

W Wang, Z Ye, H Gao, D Ouyang - Journal of Controlled Release, 2021 - Elsevier
In recent decades pharmaceutics and drug delivery have become increasingly critical in the
pharmaceutical industry due to longer time, higher cost, and less productivity of new …

[HTML][HTML] Thymoquinone (2-Isopropyl-5-methyl-1, 4-benzoquinone) as a chemopreventive/anticancer agent: Chemistry and biological effects

A Ahmad, RK Mishra, A Vyawahare, A Kumar… - Saudi Pharmaceutical …, 2019 - Elsevier
Cancer remains the topmost disorder of the mankind and number of cases is unceasingly
growing at unprecedented rates. Although the synthetic anti-cancer compounds still hold the …

Self-nanoemulsifying drug delivery system (SNEDDS) mediated improved oral bioavailability of thymoquinone: optimization, characterization, pharmacokinetic, and …

C Rathore, C Hemrajani, AK Sharma, PK Gupta… - Drug Delivery and …, 2023 - Springer
Thymoquinone (TQ) is an antioxidant, anti-inflammatory, and hepatoprotective compound
obtained from the black seed oil of Nigella sativa. However, high hydrophobicity, instability …

Oral bioavailability: issues and solutions via nanoformulations

K Pathak, S Raghuvanshi - Clinical pharmacokinetics, 2015 - Springer
The delivery of drugs through the oral route is regarded as most optimal to achieve desired
therapeutic effects and patient compliance. However, poor pharmacokinetic profiles of oral …

Nanosizing of drugs: effect on dissolution rate

SM Dizaj, Z Vazifehasl, S Salatin… - Research in …, 2015 - journals.lww.com
The solubility, bioavailability and dissolution rate of drugs are important parameters for
achieving in vivo efficiency. The bioavailability of orally administered drugs depends on their …

Development of solid self-nanoemulsifying granules (SSNEGs) of ondansetron hydrochloride with enhanced bioavailability potential

S Beg, SS Jena, CN Patra, M Rizwan, S Swain… - Colloids and surfaces B …, 2013 - Elsevier
The current work aims to prepare the solid self-nanoemulsifying granules (SSNEGs) of
ondansetron hydrochloride (ONH) to enhance its oral bioavailability by improving its …

How nanotechnology can enhance docetaxel therapy

L Zhang, N Zhang - International journal of nanomedicine, 2013 - Taylor & Francis
Docetaxel has been recognized as one of the most efficient anticancer drugs over the past
decade; however, its poor water solubility and systemic toxicity have greatly limited its …

QbD-based systematic development of novel optimized solid self-nanoemulsifying drug delivery systems (SNEDDS) of lovastatin with enhanced biopharmaceutical …

S Beg, PS Sandhu, RS Batra, RK Khurana, B Singh - Drug delivery, 2015 - Taylor & Francis
Of late, solid self-nanoemulsifying drug delivery systems (S-SNEDDS) have been
extensively sought-after owing to their superior portability, drug loading, stability and patient …

Therapeutic perspectives of the black cumin component thymoquinone: A review

C Sarkar, S Jamaddar, T Islam, M Mondal, MT Islam… - Food & Function, 2021 - pubs.rsc.org
The dietary phytochemical thymoquinone (TQ), belonging to the family of quinones, mainly
obtained from the black and angular seeds of Nigella sativa, is one of the promising …

In vivo evaluation of a self-nanoemulsifying drug delivery system for curcumin

R Nazari-Vanani, L Moezi, H Heli - Biomedicine & Pharmacotherapy, 2017 - Elsevier
Curcumin has attracted particular attention in recent years due to its great variety of
beneficial biological and pharmacological activities. However, its efficacy has been limited …