Novel drug delivery systems and disease models for pulmonary fibrosis
R Li, Y Jia, X Kong, Y Nie, Y Deng, Y Liu - Journal of Controlled Release, 2022 - Elsevier
Pulmonary fibrosis (PF) is a serious and progressive lung disease which is possibly life-
threatening. It causes lung scarring and affects lung functions including epithelial cell injury …
threatening. It causes lung scarring and affects lung functions including epithelial cell injury …
Cathepsin B-responsive nanodrug delivery systems for precise diagnosis and targeted therapy of malignant tumors
Y Li, T Mei, S Han, T Han, Y Sun, H Zhang… - Chinese Chemical …, 2020 - Elsevier
The tumor microenvironment (TME) significantly influences cancer evolution and therapeutic
efficacy. Targeting biofunctional molecules to the TME has long been appreciated as a …
efficacy. Targeting biofunctional molecules to the TME has long been appreciated as a …
Improved pharmacodynamic potential of rosuvastatin by self-nanoemulsifying drug delivery system: An in vitro and in vivo evaluation
Purpose The purpose of this proposed research was to investigate a nano-formulation
developed using self-nanoemulsifying drug delivery system (SNEDDS) to improve the …
developed using self-nanoemulsifying drug delivery system (SNEDDS) to improve the …
[HTML][HTML] 4D printing of biodegradable elastomers with tailorable thermal response at physiological temperature
N Paunović, D Meyer, A Krivitsky, AR Studart… - Journal of Controlled …, 2023 - Elsevier
Abstract 4D printing has a great potential for the manufacturing of soft robotics and medical
devices. The alliance of digital light processing (DLP) 3D printing and novel shape-memory …
devices. The alliance of digital light processing (DLP) 3D printing and novel shape-memory …
Enhanced oral bioavailability of nintedanib esylate with nanostructured lipid carriers by lymphatic targeting: In vitro, cell line and in vivo evaluation
P Patel, M Patel - European Journal of Pharmaceutical Sciences, 2021 - Elsevier
The present research work was aimed to explore the ability of nanostructured lipid carriers
(NLCs) to improve oral bioavailability of Nintedanib esylate (NE) via lymphatic uptake. The …
(NLCs) to improve oral bioavailability of Nintedanib esylate (NE) via lymphatic uptake. The …
[HTML][HTML] Rod-shaped nintedanib nanocrystals improved oral bioavailability through multiple intestinal absorption pathways
Y Zhu, Y Fu, A Zhang, X Wang, Z Zhao, Y Zhang… - European Journal of …, 2022 - Elsevier
Nintedanib (BIBF) is a biopharmaceutical classification system II (BCS II) drug that has a
good therapeutic effect for the treatment of nonsmall cell lung cancer; however, it shows …
good therapeutic effect for the treatment of nonsmall cell lung cancer; however, it shows …
Preparation, characterization, and evaluation of antioxidant activity and bioavailability of a self-nanoemulsifying drug delivery system (SNEDDS) for buckwheat …
Z Zhao, X Cui, X Ma, Z Wang - Acta biochimica et biophysica …, 2020 - academic.oup.com
The self-nanoemulsifying drug delivery system has shown many advantages in drug
delivery. In this study, a self-nanoemulsifying drug delivery system of buckwheat flavonoids …
delivery. In this study, a self-nanoemulsifying drug delivery system of buckwheat flavonoids …
SEDDS facilitate cinnamaldehyde crossing the mucus barrier: The perspective of mucus and Caco-2/HT29 co-culture models
Y Cai, L Liu, M Xia, C Tian, W Wu, B Dong… - International Journal of …, 2022 - Elsevier
Self-emulsifying drug delivery systems (SEDDS) have potential applications in the delivery
of hydrophobic components. Oral drugs are readily captured and cleared by intestinal …
of hydrophobic components. Oral drugs are readily captured and cleared by intestinal …
Long-circulating thiolated chitosan nanoparticles of nintedanib with N-acetyl cysteine for treating idiopathic pulmonary fibrosis: In vitro assessment of cytotoxicity …
S Singh, S Wairkar - International Journal of Pharmaceutics, 2023 - Elsevier
Nintedanib (NIN) is one of the FDA-approved tyrosine kinase inhibitor drugs used to treat
idiopathic pulmonary fibrosis (IPF). This study aimed to formulate a long-circulating injection …
idiopathic pulmonary fibrosis (IPF). This study aimed to formulate a long-circulating injection …
D-optimal design and development of a koumine-loaded microemulsion for rheumatoid arthritis treatment: in vivo and in vitro evaluation
Q Hu, XL Fu, YY Dong, J Ma, J Hua, JT Li… - International Journal …, 2023 - Taylor & Francis
Introduction Koumine (KME) is the most abundant active ingredient separated from
Gelsemium elegans Benth and exhibits a significant therapeutic effect on rheumatoid …
Gelsemium elegans Benth and exhibits a significant therapeutic effect on rheumatoid …