Both ornithine decarboxylase (ODC) and nitric oxide synthase (NOS) activities rely on the
availability of the common substrate L-arginine, which is directly processed by NOS to nitric …

Chronische Drucküberlastung des adulten Herzens führt zu Umbauvorgängen in der
Extrazellulärmatrix und zur Hypertrophie der Herzmuskelzellen. Dabei kommt es zur …

Hintergrund und Ziele: Das kardiale Renin-Angiotensin-Aldosteron-System (RAAS) ist an
der Entwicklung und Progredienz einer chronischen Herzinsuffizienz wesentlich beteiligt …

Polyamines are essential organic cations with multiple cellular functions. Their synthesis is
controlled by a feedback regulation whose main target is ornithine decarboxylase (ODC) …

Larkin, Jennie E., Bryan C. Frank, Renee M. Gaspard, Irena Duka, Haralambos Gavras, and
John Quackenbush. Cardiac transcriptional response to acute and chronic angiotensin II …

Las poliaminas son pequeñas moléculas con carga positiva esenciales para los procesos
de crecimiento, proliferación, diferenciación y apoptosis celular. En mamíferos, los niveles …

1 1 2 Spermine Oxidase Maintains Basal Skeletal Muscle Gene Expression and Fiber Size, 3
and Is Strongly Repressed by Conditions Page 1 1 1 2 Spermine Oxidase Maintains Basal …

A leading cause of morbidity and mortality in the developed world is cardiovascular disease
(CVD). Like many other disease processes the etiology of CVD has origins in both genetic …

Spermidine and spermine, are endogenous polyamines (PAs) that regulate cell growth and
modulate the activity of numerous ion channel proteins. In particular, intracellular PAs are …

Ornithine decarboxylase (ODC) is the first enzyme in the polyamine biosynthetic pathway.
Under normal physiological conditions, polyamine content and ODC enzyme activity are …