The CANTOS (Canakinumab Anti-inflammatory Thrombosis Outcome Study) and colchicine
trials suggest an important role of inflammasomes and their major product IL-1β (interleukin …

Hematopoietic stem cells (HSCs) support haematopoiesis throughout life and give rise to the
whole variety of cells of the immune system. Developing in the early embryo, passing …

BACKGROUND: Clonal hematopoiesis (CH), which results from an array of nonmalignant
driver gene mutations, can lead to altered immune cell function and chronic disease, and …

Somatic TP53 mutations are prevalent in normal tissue but little is known about their
association with cancer risk. Cervical liquid-based cytology (LBC), commonly known as Pap …

Hematopoietic mutations in epigenetic regulators like DNA methyltransferase 3 alpha
(DNMT3A), play a pivotal role in driving clonal hematopoiesis of indeterminate potential …

Abstract Purpose of Review Clonal hematopoiesis (CH) is a prevalent condition that results
from the acquisition of somatic mutations in hematopoietic stem cells. When these mutations …

Hematopoietic stem cell transplantation (HCT) represents a curative treatment option for
certain malignant and nonmalignant hematological diseases. Conditioning regimens before …

Nearly 56% of the global population lives in cities, with this number expected to increase to
6.6 billion or> 70% of the world's population by 2050. Given that cardiometabolic diseases …

Cis-regulatory elements control gene expression and are dynamic in their structure,
reflecting changes to the composition of diverse effector proteins over time 1–3. Here we …

Simple Summary We were motivated by the need to improve early detection of bladder
cancer (BLCA). Our aim was to uncover genetic alterations within the bladder's lining, called …