Centromere assembly and non-random sister chromatid segregation in stem cells

BL Carty, EM Dunleavy - Essays in Biochemistry, 2020 - portlandpress.com
Asymmetric cell division (ACD) produces daughter cells with separate distinct cell fates and
is critical for the development and regulation of multicellular organisms. Epigenetic …

Centromere proteins are asymmetrically distributed between newly divided germline stem and daughter cells and maintain a balanced niche in Drosophila males

AM Kochendoerfer, RS Keegan… - Molecular Biology of the …, 2023 - Am Soc Cell Biol
Stem cells can undergo asymmetric cell division (ACD) giving rise to one new stem cell and
one differentiating daughter cell. In Drosophila germline stem cells (GSCs), the centromeric …

Asymmetric histone inheritance regulates stem cell fate in Drosophila midgut

E Zion, X Chen - BioRxiv, 2020 - biorxiv.org
A fundamental question in developmental biology is how distinct cell fates are established
and maintained through epigenetic mechanisms in multicellular organisms. Here, we report …

Localization of Drosophila CENP-A to non-centromeric sites depends on the NuRD complex

E Demirdizen, M Spiller-Becker, A Förtsch… - Nucleic acids …, 2019 - academic.oup.com
Centromere function requires the presence of the histone H3 variant CENP-A in most
eukaryotes. The precise localization and protein amount of CENP-A are crucial for correct …

Unraveling the role of epigenetic regulation in asymmetric cell division during plant development

MT Alejo-Vinogradova, D Ornelas-Ayala… - Journal of …, 2022 - academic.oup.com
Asymmetric cell divisions are essential to generate different cellular lineages. In plants,
asymmetric cell divisions regulate the correct formation of the embryo, stomatal cells, apical …

CENP-A: a histone H3 variant with key roles in centromere architecture in healthy and diseased states

D Jeffery, M Lochhead, G Almouzni - Nuclear, Chromosomal, and Genomic …, 2022 - Springer
Centromeres are key architectural components of chromosomes. Here, we examine their
construction, maintenance, and functionality. Focusing on the mammalian centromere …

Biophysical factors in the regulation of asymmetric division of stem cells

A Barui, P Datta - Biological Reviews, 2019 - Wiley Online Library
Stem cells are a promising cell source for regenerative medicine due to their characteristics
of self‐renewal and differentiation. The intricate balance between these two cell fates is …

[HTML][HTML] Myt1 kinase couples mitotic cell cycle exit with differentiation in Drosophila

RJ Willms, J Zeng, SD Campbell - Cell Reports, 2020 - cell.com
The Drosophila midgut is an excellent system for characterizing cell cycle regulation in the
context of tissue homeostasis. Two major progenitor cell types populate the midgut: mitotic …

[HTML][HTML] Cell-type specific transcriptomic signatures of neocortical circuit organization and their relevance to autism

AJ Moussa, JC Wester - Frontiers in Neural Circuits, 2022 - frontiersin.org
A prevailing challenge in neuroscience is understanding how diverse neuronal cell types
select their synaptic partners to form circuits. In the neocortex, major classes of excitatory …

[HTML][HTML] TrIPP—a method for tracking the inheritance patterns of proteins in living cells—reveals retention of Tup1p, Fpr4p, and Rpd3L in the mother cell

M Auboiron, P Vasseur, S Tonazzini, A Fall, FR Castro… - Iscience, 2021 - cell.com
Inheritance of chromatin-bound proteins theoretically plays a role in the epigenetic
transmission of cellular phenotypes. Protein segregation during cell division is however …