There are multiple sources of reactive oxygen species (ROS) in the cell. As a major site of
ROS production, mitochondria have drawn considerable interest because it was recently …

Spatiotemporal regulation of the activity of a vast array of intracellular proteins and signaling
pathways by reactive oxygen species (ROS) governs normal cardiovascular function …

Activation of nucleotide-binding domain leucine-rich repeat containing family pyrin domain
containing 3 (NLRP3) inflammasome in Kupffer cells (KCs) contributes significantly to …

The effect of hypoxia, induced by incubation under low (1%) oxygen tension or by exposure
to CoCl 2, on the expression and secretion of inflammation-related adipokines was …

Oxidative stress represents excessive intracellular levels of reactive oxygen species (ROS),
which plays a major role in the pathogenesis of cardiovascular disease. Besides having a …

Reactive oxygen species (ROS) have been shown to function as important signaling
molecules in the cardiovascular system. Vascular smooth muscle cells (VSMCs) contain …

Calcium (Ca2+) uptake into the mitochondria shapes cellular Ca2+ signals and acts as a
key effector for ATP generation. In addition, mitochondria-derived reactive oxygen species …

Mitochondria have long been known to play a critical role in maintaining the bioenergetic
status of cells under physiological conditions. It was also recognized early in mitochondrial …

The last 20–25 years have seen an explosion of interest in the role of NADPH oxidase
(NOX) in cardiovascular function and disease. In vascular smooth muscle and endothelium …

Mitochondria are crucial bioenergetics powerhouses and biosynthetic hubs within cells,
which can generate and sequester toxic reactive oxygen species (ROS) in response to …