A systems approach for decoding mitochondrial retrograde signaling pathways
Mitochondrial dysfunctions activate retrograde signaling from mitochondria to the nucleus.
To identify transcription factors and their associated pathways that underlie mitochondrial …
To identify transcription factors and their associated pathways that underlie mitochondrial …
Tumour microenvironment stress promotes the development of drug resistance
Multi-drug resistance (MDR) is a leading cause of cancer-related death, and it continues to
be a major barrier to cancer treatment. The tumour microenvironment (TME) has proven to …
be a major barrier to cancer treatment. The tumour microenvironment (TME) has proven to …
Functional estrogen receptors in the mitochondria of breast cancer cells
A Pedram, M Razandi, DC Wallace… - Molecular biology of the …, 2006 - Am Soc Cell Biol
Steroid hormones have been reported to indirectly impact mitochondrial functions, attributed
to nuclear receptor-induced production of proteins that localize in this cytoplasmic organelle …
to nuclear receptor-induced production of proteins that localize in this cytoplasmic organelle …
The cellular basis for diverse responses to oxygen
NS Chandel, GRS Budinger - Free Radical Biology and Medicine, 2007 - Elsevier
Mammalian cells have divergent responses to varying oxygen levels. Cells exposed to low
oxygen levels (hypoxia) activate the transcription factor hypoxia-inducible factor-1 (HIF-1) as …
oxygen levels (hypoxia) activate the transcription factor hypoxia-inducible factor-1 (HIF-1) as …
Hypoxia triggers osteochondrogenic differentiation of vascular smooth muscle cells in an HIF-1 (hypoxia-inducible factor 1)–dependent and reactive oxygen species …
Objective—Vascular calcification is associated with high risk of cardiovascular events and
mortality. Osteochondrogenic differentiation of vascular smooth muscle cells (VSMCs) is the …
mortality. Osteochondrogenic differentiation of vascular smooth muscle cells (VSMCs) is the …
Hypoxia dysregulates the production of adiponectin and plasminogen activator inhibitor-1 independent of reactive oxygen species in adipocytes
Low plasma levels of adiponectin (hypoadiponectinemia) and elevated circulating
concentrations of plasminogen activator inhibitor (PAI)-1 are causally associated with …
concentrations of plasminogen activator inhibitor (PAI)-1 are causally associated with …
Dual role of mitochondrial reactive oxygen species in hypoxia signaling: activation of nuclear factor-κB via c-SRC–and oxidant-dependent cell death
JM Lluis, F Buricchi, P Chiarugi, A Morales… - Cancer research, 2007 - AACR
Hypoxia is a prominent feature of solid tumor development and is known to stimulate
mitochondrial ROS (mROS), which, in turn, can activate hypoxia-inducible transcription …
mitochondrial ROS (mROS), which, in turn, can activate hypoxia-inducible transcription …
Regulation of vascular calcification by reactive oxygen species
Vascular calcification is the deposition of hydroxyapatite crystals in the medial or intimal
layers of arteries that is usually associated with other pathological conditions including but …
layers of arteries that is usually associated with other pathological conditions including but …
Hypoxia and free radicals: role in tumor progression and the use of engineering-based platforms to address these relationships
A Hielscher, S Gerecht - Free Radical Biology and Medicine, 2015 - Elsevier
Hypoxia is a feature of all solid tumors, contributing to tumor progression and therapy
resistance. Through stabilization of the hypoxia-inducible factor 1 alpha (HIF-1α), hypoxia …
resistance. Through stabilization of the hypoxia-inducible factor 1 alpha (HIF-1α), hypoxia …
Structural basis for depletion of heat shock protein 90 client proteins by deguelin
Background The molecular chaperone heat shock protein 90 (Hsp90) participates in
preserving the expression and activity of various oncoproteins, including hypoxia-inducible …
preserving the expression and activity of various oncoproteins, including hypoxia-inducible …