Does Src kinase mediated vasoconstriction impair penumbral reperfusion?

HO Guldbrandsen, C Staehr, NK Iversen, DD Postnov… - Stroke, 2021 - Am Heart Assoc
Despite successful recanalization, a significant number of patients with ischemic stroke
experience impaired local brain tissue reperfusion with adverse clinical outcome. The cause …

Concentrated hypoxia‐preconditioned adipose mesenchymal stem cell‐conditioned medium improves wounds healing in full‐thickness skin defect model

B Sun, S Guo, F Xu, B Wang, X Liu… - International …, 2014 - Wiley Online Library
In recent years, the bioactive factors were utilized in exercise and athletic skin injuries. In this
research, the concentrated conditioned medium of hypoxia‐preconditioned adipose …

Counterpoint: hypoxic pulmonary vasoconstriction is not mediated by increased production of reactive oxygen species

EK Weir, SL Archer - Journal of Applied Physiology, 2006 - journals.physiology.org
NP, and Hardie DG. Does AMP-activated protein kinase couple inhibition of mitochondrial
oxidative phosphorylation by hypoxia to calcium signaling in O2-sensing cells? J Biol Chem …

[HTML][HTML] The role of Src kinase in insulin-like growth factor-dependent mitogenic signaling in vascular smooth muscle cells

J Lieskovska, Y Ling, J Badley-Clarke… - Journal of biological …, 2006 - ASBMB
Activation of the MAPK pathway mediates insulin-like growth factor-I (IGF-I)-dependent
proliferation in vascular smooth muscle cells (SMC). Our previous studies have shown that …

Mitochondrial-derived hydrogen peroxide inhibits relaxation of bovine coronary arterial smooth muscle to hypoxia through stimulation of ERK MAP kinase

Q Gao, X Zhao, M Ahmad… - American Journal of …, 2009 - journals.physiology.org
Mitochondrial reactive oxygen species (ROS) are potentially important in vascular oxygen-
sensing mechanisms because hypoxia appears to be a stimulus for mitochondrial ROS …

Chlorogenic acid inhibits hypoxia-induced pulmonary artery smooth muscle cells proliferation via c-Src and Shc/Grb2/ERK2 signaling pathway

QY Li, YF Zhu, M Zhang, L Chen, Z Zhang… - European Journal of …, 2015 - Elsevier
Chlorogenic acid (CGA), abundant in coffee and particular fruits, can modulate hypertension
and vascular dysfunction. Hypoxia-induced pulmonary artery smooth muscle cells …

PAI‐1 is a Critical Upstream Regulator of the TGF‐β1/EGF‐Induced Invasive Phenotype in Mutant p53 Human Cutaneous Squamous Cell Carcinoma

CE Wilkins-Port, CE Higgins, J Freytag… - BioMed Research …, 2007 - Wiley Online Library
The emergence of highly aggressive subtypes of human cutaneous squamous cell
carcinoma (SCC) often reflects increased autocrine/paracrine TGF‐β synthesis and …

Hypoxia induces rapid, STAT3 and ROS dependent, mitochondrial translocation of RelA (p65) and IκBα

IG Ivanova, ND Perkins - Bioscience Reports, 2019 - portlandpress.com
The nuclear factor-κB (NF-κB) family of transcription factors can directly or indirectly regulate
many important areas of biology, including immunity, inflammation and cell survival. One …

[HTML][HTML] Serum leptin concentrations and markers of immune function in overweight or obese postmenopausal women

JA Meyers, AY Liu, A McTiernan… - Journal of …, 2008 - joe.bioscientifica.com
Previous studies, by this group and others, have shown that vasoactive intestinal peptide
(VIP) stimulates aldosterone secretion, and that the actions of VIP on aldosterone secretion …

Lanthanum hydroxide inhibits vascular calcification by regulating the HIF‐1 pathway

S Wang, L Zhao, H Liu, R Han, Y Liu… - Cell Biology …, 2022 - Wiley Online Library
The main reason for the high incidence of cardiovascular disease in chronic kidney disease
(CKD) patients with vascular calcification (VC) is also the main cause of death in CKD …