[HTML][HTML] Diabetes mellitus: Classification, mediators, and complications; A gate to identify potential targets for the development of new effective treatments
Nowadays, diabetes mellitus has emerged as a significant global public health concern with
a remarkable increase in its prevalence. This review article focuses on the definition of …
a remarkable increase in its prevalence. This review article focuses on the definition of …
[HTML][HTML] Targeting HMGB1: A potential therapeutic strategy for chronic kidney disease
T Liu, Q Li, Q Jin, L Yang, H Mao, P Qu… - … Journal of Biological …, 2023 - ncbi.nlm.nih.gov
High-mobility group protein box 1 (HMGB1) is a member of a highly conserved high-mobility
group protein present in all cell types. HMGB1 plays multiple roles both inside and outside …
group protein present in all cell types. HMGB1 plays multiple roles both inside and outside …
Design and synthesis of novel benzoazoninone derivatives as potential CBSIs and apoptotic inducers: in vitro, in vivo, molecular docking, molecular dynamics, and …
Apparently, tubulin inhibitors binding to the colchicine-binding site (CBS) currently have
outstanding attention for cancer treatment. So, a series of benzo [b] azonin-2-one derivatives …
outstanding attention for cancer treatment. So, a series of benzo [b] azonin-2-one derivatives …
[HTML][HTML] Sesquiterpene nootkatone counteracted the melamine-induced neurotoxicity via repressing of oxidative stress, inflammatory, and apoptotic trajectories
Melamine (ML), a chemical substance of high nitrogen content, is used as a food adulterant.
Former evidences implied that ML could induce a variety of toxic effects including …
Former evidences implied that ML could induce a variety of toxic effects including …
Ligand-based design, synthesis, computational insights, and in vitro studies of novel N-(5-Nitrothiazol-2-yl)-carboxamido derivatives as potent inhibitors of SARS …
The global outbreak of the COVID-19 pandemic provokes scientists to make a prompt
development of new effective therapeutic interventions for the battle against SARS-CoV-2. A …
development of new effective therapeutic interventions for the battle against SARS-CoV-2. A …
[HTML][HTML] Physiological benefits of novel selenium delivery via nanoparticles
A Au, A Mojadadi, JY Shao, G Ahmad… - International Journal of …, 2023 - mdpi.com
Dietary selenium (Se) intake within the physiological range is critical to maintain various
biological functions, including antioxidant defence, redox homeostasis, growth …
biological functions, including antioxidant defence, redox homeostasis, growth …
Investigating the potential anticancer activities of antibiotics as topoisomerase II inhibitors and DNA intercalators: in vitro, molecular docking, molecular dynamics, and …
Abstract Topoisomerase II (TOP-2) is a promising molecular target for cancer therapy.
Numerous antibiotics could interact with biologically relevant macromolecules and provoke …
Numerous antibiotics could interact with biologically relevant macromolecules and provoke …
Design and synthesis of novel quinazolinone–chalcone hybrids as potential apoptotic candidates targeting caspase-3 and PARP-1: in vitro, molecular docking, and …
EA Madbouly, ESM Lashine, AA Al-Karmalawy… - New Journal of …, 2022 - pubs.rsc.org
A new series of thirty-one quinazolinone–chalcone hybrid molecules 13–43 were designed,
synthesized, and structurally characterized by different spectroscopic techniques. All the …
synthesized, and structurally characterized by different spectroscopic techniques. All the …
[HTML][HTML] Application of nanotechnology in the treatment of glomerulonephritis: current status and future perspectives
HQ Zhan, X Zhang, XL Chen, L Cheng… - Journal of …, 2024 - Springer
Glomerulonephritis (GN) is the most common cause of end-stage renal failure worldwide; in
most cases, it cannot be cured and can only delay the progression of the disease. At …
most cases, it cannot be cured and can only delay the progression of the disease. At …
[HTML][HTML] Biomarkers of oxidative stress in diabetes mellitus with diabetic nephropathy complications
P Goycheva, K Petkova-Parlapanska… - International Journal of …, 2023 - mdpi.com
The present study aimed to investigate and compare biomarkers of oxidative stress and the
activity of antioxidant enzymes in the plasma of patients with different stages of diabetic …
activity of antioxidant enzymes in the plasma of patients with different stages of diabetic …