Previously, clinical approaches to using the immune system against cancer focused on
vaccines that intended to specifically initiate or amplify a host response against evolving …

Blockbuster antibody therapies have catapulted immune‐based approaches to treat cancer
into the consciousness of mainstay clinical research. On the back of this, other emerging …

Purpose: We set out to identify Stearoyl-CoA desaturase 1 (SCD1) as a novel molecular
target in clear cell renal cell carcinoma (ccRCC) and examine its role in tumor cell growth …

Clear cell renal cell carcinoma (ccRCC) is the most common subtype of kidney cancer and
has the highest propensity to manifest as metastatic disease. Recent characterizations of the …

Context Although the development of immune checkpoint inhibitors has transformed
treatment strategies of several human malignancies, research models to study …

The immune system performs the vital function of defense against foreign antigens. In doing
so, it requires a variety of checks and balances to protect against self-antigens while …

Osteosarcoma (OS) is the most common malignant bone tumor in patients under 20 years
old. Studies have shown that cytokines play important roles in regulating immune responses …

Background: Y-box binding protein 1 (YB1) is a multifunctional protein involved in many
processes related to cancer progression and metastasis. Methods: In this study, we …

Objectives To investigate the survival characteristics of postoperative nonmetastatic renal
cell carcinoma (RCC) patients, and the predictive value of a prognostic model. Materials and …

This study reports, for the first time, development of tyrosine kinase inhibitor–loaded,
thermosensitive liposomes (TKI/TSLs) and their efficacy for treatment of renal cell carcinoma …