Physiological pathways and molecular mechanisms regulating uterine contractility

HN Aguilar, BF Mitchell - Human reproduction update, 2010 - academic.oup.com
BACKGROUND Uterine contractile activity plays an important role in many and varied
reproductive functions including sperm and embryo transport, implantation, menstruation …

Biomechanics of the human uterus

KM Myers, D Elad - Wiley Interdisciplinary Reviews: Systems …, 2017 - Wiley Online Library
The appropriate biomechanical function of the uterus is required for the execution of human
reproduction. These functions range from aiding the transport of the embryo to the …

Experiments and mechanochemical modeling of smooth muscle contraction: significance of filament overlap

SC Murtada, A Arner, GA Holzapfel - Journal of theoretical biology, 2012 - Elsevier
The main function of smooth muscle is to maintain/regulate the size of different hollow
organs through contraction and relaxation. The magnitude of the active force during …

Myometrial contractility influences oxytocin receptor (OXTR) expression in term trophoblast cells obtained from the maternal surface of the human placenta

D Szukiewicz, A Bilska, TK Mittal, A Stangret… - BMC Pregnancy and …, 2015 - Springer
Background Oxytocin (OXT) acts through its specific receptor (OXTR) and increased density
of OXTR and/or augmented sensitivity to OXT were postulated as prerequisites of normal …

Multiscale forward electromagnetic model of uterine contractions during pregnancy

PS La Rosa, H Eswaran, H Preissl, A Nehorai - BMC medical physics, 2012 - Springer
Background Analyzing and monitoring uterine contractions during pregnancy is relevant to
the field of reproductive health assessment. Its clinical importance is grounded in the need to …

A model of Stokesian peristalsis and vesicle transport in a three-dimensional closed cavity

V Aranda, R Cortez, L Fauci - Journal of biomechanics, 2015 - Elsevier
The complexity of the mechanics involved in the mammalian reproductive process is
evident. Neither an ovum nor an embryo is self-propelled, but move through the oviduct or …

The role of cellular coupling in the spontaneous generation of electrical activity in uterine tissue

J Xu, SN Menon, R Singh, NB Garnier, S Sinha… - PLoS …, 2015 - journals.plos.org
The spontaneous emergence of contraction-inducing electrical activity in the uterus at the
beginning of labor remains poorly understood, partly due to the seemingly contradictory …

An update on pacemaking in the myometrium

S Wray, MJ Taggart - The Journal of Physiology, 2024 - Wiley Online Library
Timely and efficient contractions of the smooth muscle of the uterus–the myometrium–are
crucial to a successful pregnancy outcome. These episodic contractions are regulated by …

Reconstruction of cell surface densities of ion pumps, exchangers, and channels from mRNA expression, conductance kinetics, whole-cell calcium, and current-clamp …

J Atia, C McCloskey, AS Shmygol… - PLoS computational …, 2016 - journals.plos.org
Uterine smooth muscle cells remain quiescent throughout most of gestation, only generating
spontaneous action potentials immediately prior to, and during, labor. This study presents a …

Stokesian peristaltic pumping in a three-dimensional tube with a phase-shifted asymmetry

V Aranda, R Cortez, L Fauci - Physics of fluids, 2011 - pubs.aip.org
Many physiological flows are driven by waves of muscular contractions passed along a
tubular structure. This peristaltic pumping plays a role in ovum transport in the oviduct and in …