Iron deficiency and iron overload are the most prevalent and opposite forms of dysregulated
iron metabolism that affect approximately 30 percent of the world population, in particularly …

A strong mechanistic link between the regulation of iron homeostasis and oxygen sensing is
evident in the lung, where both systems must be properly controlled to maintain lung …

Aims We previously demonstrated that iron overload induces endothelial dysfunction and
oxidative stress, which could increase the risk for atherosclerosis. However, the iron-related …

Oxidative stress can be associated with hyperoxia and hypoxia and is characterized by an
increase in reactive oxygen (ROS) and nitrogen (RNS) species generated by an underlying …

Aims Evidence is limited regarding the long-term impact of dietary iron intake on the
development of hypertension. We investigated the association between dietary intakes of …

Pulmonary hypertension (PH) is a pulmonary vascular disease characterized by increased
pulmonary artery pressures. Long standing pulmonary arterial pressure overload leads to …

Although iron is a metal involved in many vital processes due to its redox capacity, body iron
overloads lead to tissue damage, including the cardiovascular system. While …

In multicellular organisms, regulatory cell death is a crucial aspect of growth and
development. Ferroptosis, which was postulated roughly ten years ago, is a mode of cell …

Iron overload cardiomyopathy (IOC) is the leading cause of death in cases of iron overload
in patients. Previous studies demonstrated that iron overload led to cardiomyocyte …

Pulmonary arterial hypertension (PAH) is a severe cardiovascular disease that is caused by
the progressive occlusion of the distal pulmonary arteries, eventually leading to right heart …