During the past two decades, the incidence of invasive fungal infections has been
increasing dramatically. Clinical available antifungal agents have several drawbacks such …

Neglected tropical diseases (NTDs) refer to a group of infectious diseases, which though
treatable and/or preventable, remain a leading cause of morbidity and mortality among the …

African sleeping sickness or human African trypanosomiasis, caused by Trypanosoma
brucei spp., is responsible for∼ 30,000 deaths each year. Available treatments for this …

Protein lipidation is the covalent attachment of a lipid group to protein. Lipids modify large
numbers of eukaryotic proteins and regulate protein function and localization. The …

Posttranslational modifications increase the complexity and functional diversity of proteins in
response to complex external stimuli and internal changes. Among these, protein lipidations …

Abstract The Pathogen Box is a 400‐strong collection of drug‐like compounds, selected for
their potential against several of the world's most important neglected tropical diseases …

Neglected tropical diseases (NTDs) constitute a group of approximately 20 infectious
diseases that mainly affect the impoverished population without basic sanitation in tropical …

Hyperexpression of the Saccharomyces cerevisiae multidrug ATP-binding cassette (ABC)
transporter Pdr5p was driven by the pdr1-3 mutation in the Pdr1p transcriptional regulator in …

N-myristoyltransferases (NMT) add myristate to the NH2 termini of certain proteins, thereby
regulating their localization and/or biological function. Using RNA interference, this study …

Colorectal cancer is the second leading cause of malignant death, and better preventive
strategies are needed. The treatment of colonic cancer remains difficult because of the lack …