A mild and efficient α-aza-amidoalkylation for the synthesis of 5-arylaminopyrrolidinones is
presented. The key step of this reaction is the intermolecular interception of an N …

在复杂疾病的治疗过程中, 发现使用单靶点药物治疗越来越难得到预期的疗效.
基于系统生物学和网络药理学的发展, 对于复杂疾病的发病机制和病理过程的研究更加深入透彻 …

Synthesis of novel hybrid derivatives of two known scaffolds, pyrrolidine-2-one and
piperazine, is described. Initially, the Ugi reaction of phenylglyoxal, aromatic amines …

HIV-1 integrase (IN) is an essential enzyme for retroviral replication. There is no analogue
for this enzyme in human cells so that inhibition of IN will not bring strong effect on human …

HIV-1 整合酶催化前病毒DNA 整合进入宿主细胞基因组的过程是病毒复制必不可少的步骤,
所以抑制HIV-1 整合酶活性是治疗HIV-1 感染的合理策略. 目前已开发了大量HIV-1 …

Integrase (IN) is one of only three viral enzymes encoded by the human immunodeficiency
virus (HIV). The enzymatic activity of IN catalyzes the “integration” of viral double‐stranded …

A series of hexahydro-1, 6-naphthyridines were synthesized in good yields by the reaction of
3, 5-bis [(E)-arylmethylidene] tetrahydro-4 (1H)-pyridinones with cyanoacetamide in the …

This work describes the fundamental study of two bacterial toxins with computational
methods, the rational design of a potent inhibitor using molecular dynamics, as well as the …