Aberrant DNA methylation has been reported as an important phenotype in acute myeloid
leukemia. However the clinical significance of methylation changes has not been clear yet …

Prognosis of acute myeloid leukemia (AML) patients depends on patient-related features,
disease manifestations at the time of presentation, and intrinsic disease-related genetic …

Stem cells constitute the source of cells that replenishes the worn out or damaged cells in
our tissue and enable the tissue to carry out the destined function. Tissue-specific stem cells …

DNA 甲基化是一种表观遗传修饰, 抑癌基因高甲基化与多种肿瘤的发生有关.
目前化疗是治疗肿瘤最主要的手段, 而化疗耐药是化疗失败和肿瘤复发的重要原因之一 …

Epigenetics is the study of long term and stable but not necessarily heritable alterations in
transcriptional potential and gene expression profile of a cell that are not due to any …

Editorial Christopeit & Bartholdy by two waves of DNA cytosine demethylation, whereas
adult stem and progenitor cells show largely unaltered global methylation patterns. During …

Background Long noncoding RNAs (lncRNAs) plays an important role in the development of
physiology and pathology. Many reports have shown that lncRNA HOXA cluster antisense …

在临床工作中将急性髓系白血病(AML) 分为预后较好, 中度风险和预后较差的不同类型进行治疗
. 然而, 大部分被定于中等风险的AML 患者, 他们对治疗的反应并不一致, 有的治疗反应好 …

Background Long noncoding RNAs (lncRNAs) plays an important role in the development of
physiology and pathology. Many reports have shown that LncRNA HOXA cluster antisense …

DNA methylation is an epigenetic mechanism that regulates the gene transcription. Folate is
used in cellular synthesis of methyl groups, nucleic acids and amino acids. In complex …