An increasing number of newly developed drugs show bioavailability problems due to poor
water solubility. Formulating the drugs as nanosuspensions may help to overcome these …

Introduction: Many new drug substances have low aqueous solubility which can cause poor
bioavailability after oral administration. The application of solid dispersions is a useful …

Objective: This study aims to clarify the role of surfactant and drug molecular structures on
drug solubility in micellar surfactant solutions. Significance:(1) Rationale for surfactant …

The purpose of this work is to evaluate the roles of lecithin and bile salts in a new generation
of fasted simulated small intestinal fluid (FaSSIF-II), thus enhancing the closer mimic of …

Computational oral absorption simulation (COAS) is anticipated to be a powerful tool in
improving the productivity of drug discovery and development. This article reviews the …

Appropriate lubrication is important in tablet manufacturing as it lowers punch sticking
propensity and protects tooling by reducing friction between die wall and tablet during tablet …

The aqueous solubility of metformin (p Ka: 2.8 and 11.5) in the pH range of 1.2–6.8 is 300
mg/mL. Thus, the dissolution of metformin hydrochloride tablets should be pH independent …

Background: In this study, nanosuspension was prepared to improve the dissolution rate
and bioavailability of lipophilic fenofibrate. Method: Melt emulsification method combined …

Purpose Compound solubility serves as a surrogate indicator of oral biopharmaceutical
performance. Between infancy and adulthood, marked compositional changes in …

Alectinib, a lipophilic, basic, anaplastic lymphoma kinase (ALK) inhibitor with very low
aqueous solubility, has received Food and Drug Administration-accelerated approval for the …