CNS drug delivery in stroke: improving therapeutic translation from the bench to the bedside
PT Ronaldson, EI Williams, RD Betterton, JA Stanton… - Stroke, 2024 - Am Heart Assoc
Drug development for ischemic stroke is challenging as evidenced by the paucity of
therapeutics that have advanced beyond a phase III trial. There are many reasons for this …
therapeutics that have advanced beyond a phase III trial. There are many reasons for this …
[HTML][HTML] The role of circadian rhythm in neurological diseases: a translational perspective
W Huang, J Zong, Y Zhang, Y Zhou, L Zhang… - Aging and …, 2024 - ncbi.nlm.nih.gov
Intrinsic biological clocks drive the circadian rhythm, which coordinates the physiological
and pathophysiological processes in the body. Recently, a bidirectional relationship …
and pathophysiological processes in the body. Recently, a bidirectional relationship …
[HTML][HTML] Stroke in the time of circadian medicine
P Mergenthaler, JS Balami, AA Neuhaus… - Circulation …, 2024 - Am Heart Assoc
Time-of-day significantly influences the severity and incidence of stroke. Evidence has
emerged not only for circadian governance over stroke risk factors, but also for important …
emerged not only for circadian governance over stroke risk factors, but also for important …
Circadian Rhythms of the Blood-Brain Barrier and Drug Delivery
M Kim, RF Keep, SL Zhang - Circulation Research, 2024 - Am Heart Assoc
The blood-brain barrier (BBB) is a critical interface separating the central nervous system
from the peripheral circulation, ensuring brain homeostasis and function. Recent research …
from the peripheral circulation, ensuring brain homeostasis and function. Recent research …
The Circadian System Is Essential for the Crosstalk of VEGF-Notch-mediated Endothelial Angiogenesis in Ischemic Stroke
Y Zhang, X Zhao, C Guo, Y Zhang, F Zeng, Q Yin… - Neuroscience …, 2023 - Springer
Ischemic stroke is a major public health problem worldwide. Although the circadian clock is
involved in the process of ischemic stroke, the exact mechanism of the circadian clock in …
involved in the process of ischemic stroke, the exact mechanism of the circadian clock in …
[HTML][HTML] miR-100-5p activation of the autophagy response through inhibiting the mTOR pathway and suppression of cerebral infarction progression in mice
X Cao, X Zhang, J Chen, Q Sun, Y Sun, N Lin… - Aging (Albany …, 2023 - ncbi.nlm.nih.gov
In recent years, the association between microRNAs (miRNAs) and autophagy in cerebral
infarction (CI) has attracted increasingly more attention. The mammalian target of the …
infarction (CI) has attracted increasingly more attention. The mammalian target of the …
The time dimension to stroke: circadian effects on stroke outcomes and mechanisms
The circadian system is widely involved in the various pathological outcomes affected by
time dimension changes. In the brain, the master circadian clock, also known as the …
time dimension changes. In the brain, the master circadian clock, also known as the …
[HTML][HTML] Glymphatic and lymphatic communication with systemic responses during physiological and pathological conditions in the central nervous system
E Licastro, G Pignataro, JJ Iliff, Y Xiang, EH Lo… - Communications …, 2024 - nature.com
Crosstalk between central nervous system (CNS) and systemic responses is important in
many pathological conditions, including stroke, neurodegeneration, schizophrenia, epilepsy …
many pathological conditions, including stroke, neurodegeneration, schizophrenia, epilepsy …
[HTML][HTML] The role of circadian clock in astrocytes: From cellular functions to ischemic stroke therapeutic targets
Y Zhang, X Zhao, Y Zhang, F Zeng, S Yan… - Frontiers in …, 2022 - frontiersin.org
Accumulating evidence suggests that astrocytes, the abundant cell type in the central
nervous system (CNS), play a critical role in maintaining the immune response after cerebral …
nervous system (CNS), play a critical role in maintaining the immune response after cerebral …
[HTML][HTML] Hemoglobin to red cell distribution width ratio as a prognostic marker for ischemic stroke after mechanical thrombectomy
X Feng, Y Zhang, Q Li, B Wang, J Shen - Frontiers in Aging …, 2023 - frontiersin.org
Background The hemoglobin to red cell distribution width ratio (HRR) has been
experimentally associated with the prognosis of acute ischemic stroke (AIS). However, its …
experimentally associated with the prognosis of acute ischemic stroke (AIS). However, its …