Tanshinone IIA: A phytochemical as a promising drug candidate for neurodegenerative diseases
Tanshinones, lipophilic diterpenes isolated from the rhizome of Salvia miltiorrhiza, have
diverse pharmacological activities against human ailments including neurological diseases …
diverse pharmacological activities against human ailments including neurological diseases …
Evolution and emerging trends in depression research from 2004 to 2019: A literature visualization analysis
H Wang, X Tian, X Wang, Y Wang - Frontiers in psychiatry, 2021 - frontiersin.org
Depression has become a major threat to human health, and researchers around the world
are actively engaged in research on depression. In order to promote closer research, the …
are actively engaged in research on depression. In order to promote closer research, the …
Echinacoside exerts antidepressant-like effects through enhancing BDNF-CREB pathway and inhibiting neuroinflammation via regulating microglia M1/M2 …
R Lu, L Zhang, H Wang, M Li, W Feng… - Frontiers in …, 2023 - frontiersin.org
The present study was performed to investigate the antidepressant effect of echinacoside
(ECH) using chronic unpredictable mild stress (CUMS) induced depression mice and …
(ECH) using chronic unpredictable mild stress (CUMS) induced depression mice and …
[HTML][HTML] Baicalin ameliorates chronic unpredictable mild stress-induced depression through the BDNF/ERK/CREB signaling pathway
Z Jia, J Yang, Z Cao, J Zhao, J Zhang, Y Lu… - Behavioural Brain …, 2021 - Elsevier
Brain-derived neurotrophic factor (BDNF) can activate the extracellular regulated protein
kinase (ERK)/cAMP response element binding protein (CREB) cascade revealing an …
kinase (ERK)/cAMP response element binding protein (CREB) cascade revealing an …
Crocetin ameliorates chronic restraint stress-induced depression-like behaviors in mice by regulating MEK/ERK pathways and gut microbiota
S Lin, Q Li, S Jiang, Z Xu, Y Jiang, L Liu, J Jiang… - Journal of …, 2021 - Elsevier
Ethnopharmacological relevance This study aimed at determining the effects of saffron on
depression as well as its neuroprotective and pharmacological effects on the intestinal …
depression as well as its neuroprotective and pharmacological effects on the intestinal …
Targeting Aurora B kinase with Tanshinone IIA suppresses tumor growth and overcomes radioresistance
Aurora B kinase is aberrantly overexpressed in various tumors and shown to be a promising
target for anti-cancer therapy. In human oral squamous cell carcinoma (OSCC), the high …
target for anti-cancer therapy. In human oral squamous cell carcinoma (OSCC), the high …
[HTML][HTML] Pharmacological basis of tanshinone and new insights into tanshinone as a multitarget natural product for multifaceted diseases
Z Li, J Zou, D Cao, X Ma - Biomedicine & Pharmacotherapy, 2020 - Elsevier
Drug development has long included the systematic exploration of various resources.
Among these, natural products are one of the most important resources from which novel …
Among these, natural products are one of the most important resources from which novel …
[HTML][HTML] Optimized New Shengmai Powder ameliorates myocardial fibrosis in rats with heart failure by inhibition of the MAPK signaling pathway
Z Zhang, Y Song, X Zhang, S Wang, Z Jia… - Journal of …, 2024 - Elsevier
Abstract Ethnopharmacological relevance Optimized New Shengmai Powder (ONSMP) is a
traditional Chinese medicine (TCM) formula for heart failure treatment. MAPK signaling …
traditional Chinese medicine (TCM) formula for heart failure treatment. MAPK signaling …
Effect of forced treadmill exercise on stimulation of BDNF expression, depression symptoms, tactile memory and working memory in LPS-treated rats
AM Sohroforouzani, S Shakerian… - Behavioural brain …, 2022 - Elsevier
Neuroinflammation has been implicated in cognitive dysfunction and the occurrence of
depression in neurodegenerative diseases. Brain-derived neurotrophic factor (BDNF) is …
depression in neurodegenerative diseases. Brain-derived neurotrophic factor (BDNF) is …
Bushen Jieyu Tiaochong Formula reduces apoptosis of granulosa cells via the PERK-ATF4-CHOP signaling pathway in a rat model of polycystic ovary syndrome with …
X Pan, Y Liu, L Liu, B Pang, Z Sun, S Guan… - Journal of …, 2022 - Elsevier
Ethnopharmacological relevance Polycystic ovary syndrome (PCOS) is a common and
complex endocrine disorder that is also an important cause of infertility. Adverse …
complex endocrine disorder that is also an important cause of infertility. Adverse …