Overview of recent developments of pyrazole derivatives as an anticancer agent in different cell line

FE Bennani, L Doudach, Y Cherrah, Y Ramli… - Bioorganic …, 2020 - Elsevier
Pyrazole is a five-membered aromatic heterocyclic ring with two adjacent nitrogen atoms C 3
H 3 N 2 H. The presence of this nucleus in pharmacological agents of various therapeutic …

The therapeutic voyage of pyrazole and its analogs: a review

MF Khan, MM Alam, G Verma, W Akhtar… - European journal of …, 2016 - Elsevier
Pyrazole, a five membered heteroaromatic ring with two nitrogen atoms is of immense
significance. Presence of this nucleus in the pharmacological agents of diverse therapeutic …

[HTML][HTML] Functional Pyrazolo[1,5-a]pyrimidines: Current Approaches in Synthetic Transformations and Uses As an Antitumor Scaffold

A Arias-Gomez, A Godoy, J Portilla - Molecules, 2021 - mdpi.com
Pyrazolo [1, 5-a] pyrimidine (PP) derivatives are an enormous family of N-heterocyclic
compounds that possess a high impact in medicinal chemistry and have attracted a great …

Seeking heterocyclic scaffolds as antivirals against dengue virus

S De, B Aamna, R Sahu, S Parida, SK Behera… - European Journal of …, 2022 - Elsevier
Dengue is one of the most typical viral infection categorized in the Neglected Tropical
Diseases (NTDs). It is transmitted via the female Aedes aegypti mosquito to humans and …

[HTML][HTML] Structure–activity relationship of benzofuran derivatives with potential anticancer activity

J Farhat, L Alzyoud, M Alwahsh, B Al-Omari - Cancers, 2022 - mdpi.com
Simple Summary Cancer is the leading cause of death worldwide and responsible for killing
approximately 10 million people per year. Fused heterocyclic ring systems such as …

Chemistry of Ketene N,S-Acetals: An Overview

L Zhang, J Dong, X Xu, Q Liu - Chemical Reviews, 2016 - ACS Publications
Push–pull alkenes, which bear electron-donating and-accepting group (s) at both termini of
a C C double bond, respectively, are of interest not only for their unique electronic …

Domino CH sulfonylation and pyrazole annulation for fully substituted pyrazole synthesis in water using hydrophilic enaminones

Y Guo, G Wang, L Wei, JP Wan - The Journal of Organic …, 2019 - ACS Publications
The cascade reactions between NH 2-functionalized enaminones and sulfonyl hydrazines
have been developed for the synthesis of fully substituted pyrazoles. By making use of the …

Recent advanced in bioactive systems containing pyrazole fused with a five membered heterocycle

D Raffa, B Maggio, MV Raimondi, S Cascioferro… - European journal of …, 2015 - Elsevier
In this review we report the recent advances in bioactive system containing pyrazole fused
with a five membered heterocycle, covering the time span of the last decade. All of them are …

Cobalt-catalyzed Markovnikov selective sequential hydrogenation/hydrohydrazidation of aliphatic terminal alkynes

J Chen, X Shen, Z Lu - Journal of the American Chemical Society, 2020 - ACS Publications
Here, we reported for the first time a mechanistically distinctive cobalt-catalyzed
Markovnikov-type sequential semihydrogenation/hydrohydrazidation of aliphatic terminal …

H4SiW12O40-catalyzed cyclization of epoxides/aldehydes and sulfonyl hydrazides: An efficient synthesis of 3, 4-disubstituted 1H-pyrazoles

G Yang, X Xie, M Cheng, X Gao, X Lin, K Li… - Chinese Chemical …, 2022 - Elsevier
A simple and efficient method for the synthesis of pyrazoles through a silicotungstic acid (H 4
SiW 12 O 40)-catalyzed cyclization of epoxides/aldehydes and sulfonyl hydrazides has been …