Asymmetric cell division, which includes cell polarization and cytokinesis, is essential for
generating cell diversity during development. The budding yeast Saccharomyces cerevisiae …

Endocytosis, the process whereby the plasma membrane invaginates to form vesicles, is
essential for bringing many substances into the cell and for membrane turnover. The …

652 is energetically unfavourable until there is a nucleus of three associating monomers and
in vitro this stage of filament formation is denoted the lag phase. In vivo, ABPs are crucial to …

All cells undergo rapid remodeling of their actin networks to regulate such critical processes
as endocytosis, cytokinesis, cell polarity, and cell morphogenesis. These events are driven …

Evidence from many organisms has shown that the accumulation of reactive oxygen species
(ROS) has a detrimental effect on cell well-being. High levels of ROS have been linked to …

Several determinants of aging, including metabolic capacity and genetic stability, are
recognized in both yeast and humans. However, many aspects of the pathways leading to …

Interactions between mitochondria and the cytoskeleton are essential for normal
mitochondrial morphology, motility and distribution. While microtubules and their motors …

Increasing evidence from a variety of cell types has highlighted the importance of the actin
cytoskeleton during endocytosis. No longer is actin viewed as a passive barrier that must be …

Endocytosis is a fundamental eukaryotic process required for remodelling plasma-
membrane lipids and protein to ensure appropriate membrane composition. Increasing …

AIM: Smooth muscle 22 alpha (SM22α) is not required for the development and basal
homeostatic function of smooth muscle cells (SMCs). However, a recent study demonstrated …