An elevated level of total homocysteine (tHcy) in blood, denoted hyperhomocysteinemia, is
emerging as a prevalent and strong risk factor for atherosclerotic vascular disease in the …

Folate being an important vitamin of B Complex group in our diet plays an important role not
only in the synthesis of DNA but also in the maintenance of methylation reactions in the …

In this article, we reviewed the association between alcohol drinking and head and neck
cancer (HNC) and its subsites, using the available literature. Alcohol drinking is an …

Within the last few years, knowledge about vitamins has increased dramatically. This new
edition of a bestseller presents comprehensive summaries that analyze the chemical …

Tetrahydrofolate (THF) polyglutamates are a family of cofactors that carry and chemically
activate one‐carbon units for biosynthesis. THF‐mediated one‐carbon metabolism is a …

The final unique stage in the metabolism of L-isoleucine involves the cleavage of 2-
methylacetoacetyl-CoA to acetyl-CoA and propionyl-CoA (Section 10.4). The propionyl-CoA …

Three topics affecting cobalamin, folate, and homocysteine that have generated interest,
activity, and advances in recent years are discussed. These are:(I) the application of an …

On the basis of recent retrospective and prospective studies, it is now widely accepted that
increased total plasma homocysteine is a risk factor for cardiovascular disease. Impaired …

Methionine synthase catalyzes the remethylation of homocysteine to methionine via a
reaction in which methylcobalamin serves as an intermediate methyl carrier. Over time, the …

As many as one-third of mutations in a gene result in the corresponding enzyme having an
increased Michaelis constant, or K m,(decreased binding affinity) for a coenzyme, resulting …