Emerging approaches for restoration of hearing and vision
Impairments of vision and hearing are highly prevalent conditions limiting the quality of life
and presenting a major socioeconomic burden. For a long time, retinal and cochlear …
and presenting a major socioeconomic burden. For a long time, retinal and cochlear …
Immune responses in the mammalian inner ear and their implications for AAV-mediated inner ear gene therapy
Y Ishibashi, CYW Sung, M Grati, W Chien - Hearing Research, 2023 - Elsevier
Abstract Adeno-associated virus (AAV)-mediated inner ear gene therapy is a promising
treatment option for hearing loss and dizziness. Several studies have shown that AAV …
treatment option for hearing loss and dizziness. Several studies have shown that AAV …
Cochlear gene therapy with ancestral AAV in adult mice: complete transduction of inner hair cells without cochlear dysfunction
J Suzuki, K Hashimoto, R Xiao, LH Vandenberghe… - Scientific reports, 2017 - nature.com
The use of viral vectors for inner ear gene therapy is receiving increased attention for
treatment of genetic hearing disorders. Most animal studies to date have injected viral …
treatment of genetic hearing disorders. Most animal studies to date have injected viral …
Gene therapy restores balance and auditory functions in a mouse model of Usher syndrome
K Isgrig, JW Shteamer, IA Belyantseva, MC Drummond… - Molecular therapy, 2017 - cell.com
Dizziness and hearing loss are among the most common disabilities. Many forms of
hereditary balance and hearing disorders are caused by abnormal development of …
hereditary balance and hearing disorders are caused by abnormal development of …
[HTML][HTML] Canalostomy as a surgical approach to local drug delivery into the inner ears of adult and neonatal mice
JY Guo, L He, TF Qu, YY Liu, K Liu… - Journal of Visualized …, 2018 - ncbi.nlm.nih.gov
Local delivery of therapeutic drugs into the inner ear is a promising therapy for inner ear
diseases. Injection through semicircular canals (canalostomy) has been shown to be a …
diseases. Injection through semicircular canals (canalostomy) has been shown to be a …
Systemic gene delivery transduces the enteric nervous system of guinea pigs and cynomolgus macaques
SE Gombash, CJ Cowley, JA Fitzgerald, CA Lepak… - Gene therapy, 2017 - nature.com
Abstract Characterization of adeno-associated viral vector (AAV) mediated gene delivery to
the enteric nervous system (ENS) was recently described in mice and rats. In these proof-of …
the enteric nervous system (ENS) was recently described in mice and rats. In these proof-of …
[HTML][HTML] Extended time frame for restoring inner ear function through gene therapy in Usher1G preclinical model
G Lahlou, C Calvet, F Simon, V Michel, L Alciato… - JCI insight, 2024 - ncbi.nlm.nih.gov
Neonatal gene therapy has been shown to prevent inner ear dysfunction in mouse models
of Usher syndrome type I (USH1), the most common genetic cause of combined deafness …
of Usher syndrome type I (USH1), the most common genetic cause of combined deafness …
rAAV-mediated cochlear gene therapy: prospects and challenges for clinical application
Over the last decade, pioneering molecular gene therapy for inner-ear disorders have
achieved experimental hearing improvements after a single local or systemic injection of …
achieved experimental hearing improvements after a single local or systemic injection of …
Co-transduction of dual-adeno-associated virus vectors in the neonatal and adult mouse utricles
ZR Chen, JY Guo, L He, S Liu, JY Xu… - Frontiers in Molecular …, 2022 - frontiersin.org
Adeno-associated virus (AAV)-mediated gene transfer is an efficient method of gene over-
expression in the vestibular end organs. However, AAV has limited usefulness for delivering …
expression in the vestibular end organs. However, AAV has limited usefulness for delivering …
A single cisterna magna injection of AAV leads to binaural transduction in mice
Viral-mediated gene augmentation, silencing, or editing offers tremendous promise for the
treatment of inherited and acquired deafness. Inner-ear gene therapies often require a safe …
treatment of inherited and acquired deafness. Inner-ear gene therapies often require a safe …