[HTML][HTML] Therapeutic application of quercetin in aging-related diseases: SIRT1 as a potential mechanism

Z Cui, X Zhao, FK Amevor, X Du, Y Wang, D Li… - Frontiers in …, 2022 - frontiersin.org
Quercetin, a naturally non-toxic flavonoid within the safe dose range with antioxidant, anti-
apoptotic and anti-inflammatory properties, plays an important role in the treatment of aging …

Polyunsaturated fatty acids drive lipid peroxidation during ferroptosis

MS Mortensen, J Ruiz, JL Watts - Cells, 2023 - mdpi.com
Ferroptosis is a form of regulated cell death that is intricately linked to cellular metabolism. In
the forefront of research on ferroptosis, the peroxidation of polyunsaturated fatty acids has …

Thrombin induces ACSL4-dependent ferroptosis during cerebral ischemia/reperfusion

Q Tuo, Y Liu, Z Xiang, HF Yan, T Zou, Y Shu… - Signal transduction and …, 2022 - nature.com
Ischemic stroke represents a significant danger to human beings, especially the elderly.
Interventions are only available to remove the clot, and the mechanism of neuronal death …

Pharmacological inhibition of ferroptosis as a therapeutic target for neurodegenerative diseases and strokes

Y Wang, S Wu, Q Li, H Sun, H Wang - Advanced Science, 2023 - Wiley Online Library
Emerging evidence suggests that ferroptosis, a unique regulated cell death modality that is
morphologically and mechanistically different from other forms of cell death, plays a vital role …

Salidroside attenuates neuronal ferroptosis by activating the Nrf2/HO1 signaling pathway in Aβ1-42-induced Alzheimer's disease mice and glutamate-injured HT22 …

S Yang, Z Xie, T Pei, Y Zeng, Q Xiong, H Wei, Y Wang… - Chinese Medicine, 2022 - Springer
Background Alzheimer's disease (AD) is a neurodegenerative disease. Ferroptosis plays a
critical role in neurodegenerative diseases. Nuclear factor E2-related factor 2 (Nrf2) is …

EGFR is a potential dual molecular target for cancer and Alzheimer's disease

HJ Choi, YJ Jeong, J Kim, HS Hoe - Frontiers in Pharmacology, 2023 - frontiersin.org
Many researchers are attempting to identify drugs that can be repurposed as effective
therapies for Alzheimer's disease (AD). Several recent studies have highlighted epidermal …

Identification of ferroptosis-related genes in Alzheimer's disease based on bioinformatic analysis

Y Wang, G Chen, W Shao - Frontiers in Neuroscience, 2022 - frontiersin.org
Introduction Alzheimer's disease (AD) is the most prevalent cause of dementia, and
emerging evidence suggests that ferroptosis is involved in the pathological process of AD …

The role of iron metabolism, lipid metabolism, and redox homeostasis in Alzheimer's disease: from the perspective of ferroptosis

L Wu, X Xian, Z Tan, F Dong, G Xu, M Zhang… - Molecular …, 2023 - Springer
In the development of Alzheimer's disease (AD), cell death is common. Novel cell death form—
ferroptosis is discovered in recent years. Ferroptosis is an iron-regulated programmed cell …

[HTML][HTML] Molecular mechanism and potential therapeutic targets of necroptosis and ferroptosis in Alzheimer's disease

S Chavoshinezhad, E Beirami, E Izadpanah… - Biomedicine & …, 2023 - Elsevier
Abstract Alzheimer's disease (AD), a neurodegenerative condition, is defined by
neurofibrillary tangles, amyloid plaques, and gradual cognitive decline. Regardless of the …

Iron and ferroptosis more than a suspect: beyond the most common mechanisms of neurodegeneration for new therapeutic approaches to cognitive decline and …

M Cerasuolo, I Di Meo, MC Auriemma, F Trojsi… - International Journal of …, 2023 - mdpi.com
Neurodegeneration is a multifactorial process that involves multiple mechanisms. Examples
of neurodegenerative diseases are Parkinson's disease, multiple sclerosis, Alzheimer's …