Metalloenzymes are central to a wide range of essential biological activities, including
nucleic acid modification, protein degradation, and many others. The role of metalloenzymes …

Human immunodeficiency virus type-1 (HIV-1) integrase is one of the three virally encoded
enzymes required for replication and therefore a rational target for chemotherapeutic …

Abstract HIV‐1 integrase (IN) catalyzes the integration of proviral DNA into the host genome,
an essential step for viral replication. Inhibition of IN catalytic activity provides an attractive …

HIV integrase (IN) catalyzes the insertion into the genome of the infected human cell of viral
DNA produced by the retrotranscription process. The discovery of raltegravir validated the …

Among a large number of HIV-1 integrase (IN) inhibitors, the 8-hydroxy-[1, 6] naphthyridines
(ie, L-870,810) were one of the promising class of antiretroviral drugs developed by Merck …

In spite of significant progress in anti-HIV-1 therapy, current antiviral chemo-therapy still
suffers from deleterious side effects and emerging drug resistance. Therefore, the …

Highlights•Overview of structural and functional properties of HIV-1 integrase
(IN).•Classifying the HIV-1 integrase strand transfer inhibitors (INSTIs) into ten …

Human cytomegalovirus (HCMV) infects individuals of all ages and establishes a lifelong
latency. Current antiviral drugs are suboptimal in efficacy and safety and ineffective against …

HIV integrase is one of the three enzymes encoded by HIV genome and is essential for viral
replication, but integrase inhibitors as marketed drugs have just very recently started to …

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