Monogenic and polygenic inheritance become instruments for clonal selection
Clonally expanded blood cells that contain somatic mutations (clonal haematopoiesis) are
commonly acquired with age and increase the risk of blood cancer,,,,,,,–. The blood clones …
commonly acquired with age and increase the risk of blood cancer,,,,,,,–. The blood clones …
GWAS of mosaic loss of chromosome Y highlights genetic effects on blood cell differentiation
C Terao, Y Momozawa, K Ishigaki, E Kawakami… - Nature …, 2019 - nature.com
Mosaic loss of chromosome Y (mLOY) is frequently observed in the leukocytes of ageing
men. However, the genetic architecture and biological mechanisms underlying mLOY are …
men. However, the genetic architecture and biological mechanisms underlying mLOY are …
Longitudinal changes in the frequency of mosaic chromosome Y loss in peripheral blood cells of aging men varies profoundly between individuals
M Danielsson, J Halvardson, H Davies… - European Journal of …, 2020 - nature.com
Mosaic loss of chromosome Y (LOY) is the most common somatic genetic aberration and is
associated with increased risk for all-cause mortality, various forms of cancer and …
associated with increased risk for all-cause mortality, various forms of cancer and …
Mosaic chromosome Y loss is associated with alterations in blood cell counts in UK Biobank men
Mosaic loss of Y chromosome (mLOY) is the most frequently detected somatic copy number
alteration in leukocytes of men. In this study, we investigate blood cell counts as a potential …
alteration in leukocytes of men. In this study, we investigate blood cell counts as a potential …
Somatic mosaicism of sex chromosomes in the blood and brain
In the blood, mosaic somatic aneuploidy (mSA) of all chromosomes has been found to be
associated with adverse health outcomes, including hematological cancer. Sex …
associated with adverse health outcomes, including hematological cancer. Sex …
Loss of Y in leukocytes, dysregulation of autosomal immune genes and disease risks
JP Dumanski, J Halvardson, H Davies… - BioRxiv, 2019 - biorxiv.org
Mosaic loss of chromosome Y (LOY) in leukocytes has been associated with many diseases,
yet it remains unclear whether this form of clonal mosaicism exerts a direct physiological …
yet it remains unclear whether this form of clonal mosaicism exerts a direct physiological …
Why Y? Downregulation of chromosome Y genes potentially contributes to elevated cancer risk
DW Brown, MJ Machiela - JNCI: Journal of the National Cancer …, 2020 - academic.oup.com
On average, men die earlier than women (1). Although differences in environmental,
lifestyle, and exposure factors certainly explain some of the earlier mortality of men, recent …
lifestyle, and exposure factors certainly explain some of the earlier mortality of men, recent …