Neurogenetic disorders across the lifespan: from aberrant development to degeneration
RA Hickman, SA O'Shea, MF Mehler… - Nature Reviews …, 2022 - nature.com
Intellectual disability and autism spectrum disorder (ASD) are common, and genetic testing
is increasingly performed in individuals with these diagnoses to inform prognosis, refine …
is increasingly performed in individuals with these diagnoses to inform prognosis, refine …
Calcium and activity-dependent signaling in the developing cerebral cortex
A Arjun McKinney, R Petrova… - Development, 2022 - journals.biologists.com
Calcium influx can be stimulated by various intra-and extracellular signals to set coordinated
gene expression programs into motion. As such, the precise regulation of intracellular …
gene expression programs into motion. As such, the precise regulation of intracellular …
[HTML][HTML] A longitudinal study on cognitive aging in autism
C Torenvliet, AP Groenman, TA Radhoe… - Psychiatry …, 2023 - Elsevier
Longitudinal studies on cognitive aging in autism are scarce, and largely underpowered, yet
essential to obtain more conclusive results on cognitive changes in autism during adulthood …
essential to obtain more conclusive results on cognitive changes in autism during adulthood …
Effects of age on the hippocampus and verbal memory in adults with autism spectrum disorder: Longitudinal versus cross‐sectional findings
Research studying aging in adults with autism spectrum disorder (ASD) is growing, but
longitudinal work is needed. Autistic adults have increased risk of dementia, altered …
longitudinal work is needed. Autistic adults have increased risk of dementia, altered …
Neuron-specific transcriptomic signatures indicate neuroinflammation and altered neuronal activity in ASD temporal cortex
Autism spectrum disorder (ASD) is a highly heterogeneous disorder, yet transcriptomic
profiling of bulk brain tissue has identified substantial convergence among dysregulated …
profiling of bulk brain tissue has identified substantial convergence among dysregulated …
Schizophrenia: a developmental disorder with a risk of non-specific but avoidable decline
The onset of schizophrenia is determined by biological and social risk factors operating
predominantly during development. These result in subtle deviations in brain structure and …
predominantly during development. These result in subtle deviations in brain structure and …
Self‐reported cognitive decline among middle and older age autistic adults
CB Klein, GA McQuaid, RA Charlton… - Autism …, 2023 - Wiley Online Library
Very little is known about autistic adults as they age. Early evidence suggests a potentially
high risk for dementia and atypical cognitive decline in autistic middle and older age adults …
high risk for dementia and atypical cognitive decline in autistic middle and older age adults …
[HTML][HTML] Environmental and lifestyle risk factors for early-onset dementia: a systematic review
M Bosi, M Malavolti, C Garuti, M Tondelli… - Acta Bio Medica …, 2022 - ncbi.nlm.nih.gov
Methods: We conducted a literature search in PubMed and EMBASE databases up to May 6,
2022, to retrieve epidemiological studies evaluating the effect of environmental and lifestyle …
2022, to retrieve epidemiological studies evaluating the effect of environmental and lifestyle …
Neurodevelopmental disorders and microcephaly: how apoptosis, the cell cycle, tau and amyloid-β precursor protein APPly
DK Sokol, DK Lahiri - Frontiers in Molecular Neuroscience, 2023 - frontiersin.org
Recent studies promote new interest in the intersectionality between autism spectrum
disorder (ASD) and Alzheimer's Disease. We have reported high levels of Amyloid-β …
disorder (ASD) and Alzheimer's Disease. We have reported high levels of Amyloid-β …
Disease-and stage-specific alterations of the oral and fecal microbiota in Alzheimer's disease
A Troci, S Philippen, P Rausch, J Rave… - PNAS …, 2024 - academic.oup.com
Microbial communities in the intestinal tract are suggested to impact the ethiopathogenesis
of Alzheimer's disease (AD). The human microbiome might modulate neuroinflammatory …
of Alzheimer's disease (AD). The human microbiome might modulate neuroinflammatory …