Multiple sclerosis (MS) is traditionally seen as an inflammatory demyelinating disease,
characterized by the formation of focal demyelinated plaques in the white matter of the …

The immune system and the nervous system maintain extensive communication,
including'hardwiring'of sympathetic and parasympathetic nerves to lymphoid organs …

Genome-wide studies have identified genetic variants linked to neurologic diseases.
Environmental factors also play important roles, but no methods are available for their …

Inflammation-mediated neurodegeneration occurs in the acute and the chronic phases of
multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis …

Experimental autoimmune encephalomyelitis (EAE) is a T cell-mediated autoimmune
disease of the CNS. Metformin is the most widely used drug for diabetes and mediates its …

Objective To evaluate the ability of mesenchymal stem cells (MSCs), a subset of adult stem
cells from bone marrow, to cure experimental autoimmune encephalomyelitis. Methods The …

Oligodendrocyte death and demyelination are hallmarks of multiple sclerosis (MS). Here we
show that ATP signaling can trigger oligodendrocyte excitotoxicity via activation of calcium …

Background In multiple sclerosis, inflammation can successfully be prevented, while
promoting repair is still a major challenge. Microglial cells, the resident phagocytes of the …

Olig1 and Olig2 are closely related basic helix-loop-helix (bHLH) transcription factors that
are expressed in myelinating oligodendrocytes and their progenitor cells in the developing …

Recent studies in multiple sclerosis and its animal model, experimental autoimmune
encephalomyelitis (EAE), point to the fact that even in the early phase of inflammation …