The endothelial angiopoietin (ANG)–TIE growth factor receptor pathway regulates vascular
permeability and pathological vascular remodelling during inflammation, tumour …

Angiogenesis, the growth of blood vessels, is a fundamental biological process that controls
embryonic development and is also involved in numerous life-threatening human diseases …

Endothelial cells that form the inner layer of blood and lymphatic vessels are important
regulators of vascular functions and centrally involved in the pathogenesis of vascular …

Abstracts The Angiopoietin/Tie system acts as a vascular specific ligand/receptor system to
control endothelial cell survival and vascular maturation. The Angiopoietin family includes …

Angiopoietin-1 (Ang1) has powerful vascular protective effects: suppressing plasma
leakage, inhibiting vascular inflammation, and preventing endothelial death. Preclinical …

The angiopoietin (Ang) growth factors and the endothelial Tie receptors regulate blood and
lymphatic vessel development, and vascular permeability, inflammation, angiogenic …

Significance: Forces are important in the cardiovascular system, acting as regulators of
vascular physiology and pathology. Residing at the blood vessel interface, cells (endothelial …

Angiopoietins are ligands of the Tie2 receptor that control angiogenic remodeling in a
context-dependent manner. Tie signaling is involved in multiple steps of the angiogenic …

Tie1 is a mechanistically poorly characterized endothelial cell (EC)-specific orphan receptor.
Yet, Tie1 deletion is embryonic lethal and Tie1 has been implicated in critical vascular …

Biophysical and biochemical cues work in concert to regulate angiogenesis. These cues
guide angiogenesis during development and wound healing. Abnormal cues contribute to …