Hotspot Coevolution Is a Key Identifier of Near-Native Protein Complexes
Protein–protein interactions play a key role in mediating numerous biological functions, with
more than half the proteins in living organisms existing as either homo-or hetero-oligomeric …
more than half the proteins in living organisms existing as either homo-or hetero-oligomeric …
[HTML][HTML] Considering both small and large scale motions of vascular endothelial growth factor (VEGF) is crucial for reliably predicting its binding affinities to DNA …
Vascular endothelial growth factor 165 (VEGF165), a predominant isoform of VEGF signal
proteins, is an ideal target for developing drugs against various diseases. It is composed of a …
proteins, is an ideal target for developing drugs against various diseases. It is composed of a …
Influence of amino acid mutations and small molecules on targeted inhibition of proteins involved in Cancer
Background: Protein-protein interactions (PPIs) are of crucial importance in regulating the
biological processes of cells both in normal and diseased conditions. Significant progress …
biological processes of cells both in normal and diseased conditions. Significant progress …
Match_Motif: A rapid computational tool to assist in protein–protein interaction design
M Zacharias - Protein Science, 2022 - Wiley Online Library
In order to generate protein assemblies with a desired function, the rational design of protein–
protein binding interfaces is of significant interest. Approaches based on random …
protein binding interfaces is of significant interest. Approaches based on random …
Methods of computational interactomics for investigating interactions of human proteoforms
EV Poverennaya, OI Kiseleva, AS Ivanov… - Biochemistry …, 2020 - Springer
Abstract Human genome contains ca. 20,000 protein-coding genes that could be translated
into millions of unique protein species (proteoforms). Proteoforms coded by a. single gene …
into millions of unique protein species (proteoforms). Proteoforms coded by a. single gene …
Novel prediction methods for virtual drug screening
J Mesarić - arXiv preprint arXiv:2202.06635, 2022 - arxiv.org
Drug development is an expensive and time-consuming process where thousands of
chemical compounds are being tested in order to find those possessing drug-like properties …
chemical compounds are being tested in order to find those possessing drug-like properties …
Mutational effects on protein–protein interactions
Interatomically, protein's ability to enact careful and tight interactions with its biomolecular
partners is pivotal necessitating proper biological function. Protein–protein interactions …
partners is pivotal necessitating proper biological function. Protein–protein interactions …
[HTML][HTML] The impact of the suppression of highly connected protein interactions on the corona virus infection
F Torres, M Kiwi, IK Schuller - Scientific Reports, 2022 - nature.com
Several highly effective Covid-19 vaccines are in emergency use, although more-infectious
coronavirus strains, could delay the end of the pandemic even further. Because of this, it is …
coronavirus strains, could delay the end of the pandemic even further. Because of this, it is …
Computational Analysis of Antibody Binding Mechanisms to the Omicron RBD of SARS-CoV-2 Spike Protein: Identification of Epitopes and Hotspots for Developing …
MR Alshahrani - 2023 - search.proquest.com
The advent of the Omicron strain of SARS-CoV-2 has elicited apprehension regarding its
potential influence on the effectiveness of current vaccines and antibody treatments. The …
potential influence on the effectiveness of current vaccines and antibody treatments. The …
[HTML][HTML] EB 病毒相关伯基特淋巴瘤差异基因表达分析
郑雨薇， 肖华， 王维文， 刘雯 - 2019 - jms.qdu.edu.cn
目的从分子层面分析EB 病毒(EBV) 相关伯基特淋巴瘤(BL) 的差异表达基因(DEGs),
为其诊疗提供新的思路. 方法从美国国立生物技术信息中心(NCBI) 获取EBV 阳性与阴性BL …
为其诊疗提供新的思路. 方法从美国国立生物技术信息中心(NCBI) 获取EBV 阳性与阴性BL …