[HTML][HTML] Multi-omics approaches to disease
High-throughput technologies have revolutionized medical research. The advent of
genotyping arrays enabled large-scale genome-wide association studies and methods for …
genotyping arrays enabled large-scale genome-wide association studies and methods for …
Multi-omics integration in biomedical research–A metabolomics-centric review
Recent advances in high-throughput technologies have enabled the profiling of multiple
layers of a biological system, including DNA sequence data (genomics), RNA expression …
layers of a biological system, including DNA sequence data (genomics), RNA expression …
Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations
Ulcerative colitis and Crohn's disease are the two main forms of inflammatory bowel disease
(IBD). Here we report the first trans-ancestry association study of IBD, with genome-wide or …
(IBD). Here we report the first trans-ancestry association study of IBD, with genome-wide or …
HaploReg v4: systematic mining of putative causal variants, cell types, regulators and target genes for human complex traits and disease
More than 90% of common variants associated with complex traits do not affect proteins
directly, but instead the circuits that control gene expression. This has increased the urgency …
directly, but instead the circuits that control gene expression. This has increased the urgency …
[PDF][PDF] Environment drives selection and function of enhancers controlling tissue-specific macrophage identities
Macrophages reside in essentially all tissues of the body and play key roles in innate and
adaptive immune responses. Distinct populations of tissue macrophages also acquire …
adaptive immune responses. Distinct populations of tissue macrophages also acquire …
[HTML][HTML] The role of regulatory variation in complex traits and disease
FW Albert, L Kruglyak - Nature Reviews Genetics, 2015 - nature.com
We are in a phase of unprecedented progress in identifying genetic loci that cause variation
in traits ranging from growth and fitness in simple organisms to disease in humans …
in traits ranging from growth and fitness in simple organisms to disease in humans …
Non-coding RNAs in cardiovascular diseases: diagnostic and therapeutic perspectives
Recent research has demonstrated that the non-coding genome plays a key role in genetic
programming and gene regulation during development as well as in health and …
programming and gene regulation during development as well as in health and …
[PDF][PDF] Common disease is more complex than implied by the core gene omnigenic model
The evidence that most adult-onset common diseases have a polygenic genetic architecture
fully consistent with robust biological systems supported by multiple back-up mechanisms is …
fully consistent with robust biological systems supported by multiple back-up mechanisms is …
Omics sciences for systems biology in Alzheimer's disease: State-of-the-art of the evidence
Alzheimer's disease (AD) is characterized by non-linear, genetic-driven pathophysiological
dynamics with high heterogeneity in biological alterations and disease spatial-temporal …
dynamics with high heterogeneity in biological alterations and disease spatial-temporal …
Network approaches to systems biology analysis of complex disease: integrative methods for multi-omics data
In the past decade, significant progress has been made in complex disease research across
multiple omics layers from genome, transcriptome and proteome to metabolome. There is an …
multiple omics layers from genome, transcriptome and proteome to metabolome. There is an …