A drug's aqueous solubility is defined as the ability to dissolve in a particular solvent, and it
is currently a major hurdle in bringing new drug molecules to the market. According to some …

Efficient drug delivery systems (DDSs) play a pivotal role in ensuring pharmaceuticals'
targeted and effective administration. However, the intricate interplay between drug …

The solubility of dapagliflozin propanediol monohydrate (DPM) in supercritical carbon
dioxide (SC-CO 2) was determined for the first time. The operating temperature and …

Chronic inflammation is a common underlying factor in many major diseases, including
heart disease, diabetes, cancer, and autoimmune disorders, and is responsible for up to …

Psychiatric and neurodegenerative disorders are amongst the most prevalent and
debilitating diseases, but current treatments either have low success rates, greatly due to the …

Oral delivery has become the route of choice among all other types of drug administrations.
However, typical chronic disease drugs are often poorly water-soluble, have low dissolution …

Introduction Oral administration of poorly water-soluble drugs (PWSDs) is generally related
to low bioavailability, leading to high drug doses, multiple side effects, and low patient …

Allopurinol (ALO) is a medication that treats gout and kidney stones by lowering uric acid
synthesis in the blood. The biopharmaceutics classification system (BCS) IV drug exhibits …

Crystals with an acicular shape are a “nightmare” to many chemical engineers due to their
poor powder properties, posing numerous challenges in purification, filtration, washing, and …

Critical-sized bone defects resulting from severe trauma and open fractures cannot
spontaneously heal and require surgical intervention. Limitations of traditional bone grafting …