Drugs with low water solubility are predisposed to low and variable oral bioavailability and,
therefore, to variability in clinical response. Despite significant efforts to “design in” …

The biopharmaceutical properties—especially the solubility and permeability—of a molecule
contribute to its overall therapeutic efficacy. The newer tools of drug discovery have caused …

Amorphous solid dispersions (ASDs) are widely utilized in the pharmaceutical industry for
bioavailability enhancement of low solubility drugs. The important factors governing the …

This review examines the literature concerning the thermal properties of natural and
semisynthetic cyclodextrins and their inclusion compounds. Particular emphasis is given to …

The use of high-throughput screening and similar techniques in drug discovery has put a
number of evolutionary pressures on drug candidates such that over time there is a …

Cyclodextrins (CyDs) are cyclic oligosaccharides, containing a minimum of six D-(+)-
glycopyranose units attached by α-1, 4-linkages produced by the action of the cyclodextrin …

Cyclodextrins (CYDs) are cyclic non-reducing oligosaccharides built up from six, seven or
eight glucopyranose units (α-, β-or γ-CYD, respectively). Many drugs are able to form an …

Drug dissolution from a solid dispersion is dependent on the technology employed to
prepare the dispersion and on the proportion and properties of the carrier used. The …

Although praziquantel (PZQ) is the primary drug of choice in the treatment of
schistosomiasis, its poor solubility has restricted its delivery via the oral route. In spite of its …

The complexing, solubilizing and amorphizing abilities towards ketoprofen and ibuprofen of
native β-cyclodextrin and some randomly substituted amorphous derivatives (methyl …