Abstract Background & Aims Obesity and non‐alcoholic fatty liver disease (NAFLD) are
known risk factors for gastrointestinal (GI) cancers. However, GI carcinogenesis in lean …

The gut microbiota is a major factor contributing to the regulation of energy homeostasis and
has been linked to both excessive body weight and accumulation of fat mass (ie, overweight …

The molecular events governing skeletal muscle glucose uptake have pharmacological
potential for managing insulin resistance in conditions such as obesity, diabetes, and …

Background Metabolic dysfunction and cachexia are associated with poor cancer prognosis.
With no pharmacological treatments, it is crucial to define the molecular mechanisms …

Polycystic ovary syndrome is a common endocrine disorder characterized by hormonal
imbalances and various metabolic abnormalities linked to insulin resistance via a vicious …

Insulin resistance, also known as impaired insulin sensitivity, is the result of a decreased
reaction of insulin signaling to blood glucose levels. This state is observed when muscle …

Ground-breaking discoveries have established 5′-AMP-activated protein kinase (AMPK) as
a central sensor of metabolic stress in cells and tissues. AMPK is activated through cellular …

Insulin is a polypeptide hormone synthesized and secreted by pancreatic β-cells. It plays an
important role as a metabolic hormone. Insulin influences the metabolism of glucose …

Background: Cancer cachexia (CC) is a debilitating syndrome severely impacting patients'
quality of life and survivorship. We aimed to investigate the health care …

Background: Individuals diagnosed with an obesity-related cancer (ORC survivors) are at an
elevated risk of incident diabetes compared with cancer-free individuals, but whether this …