Most therapies for treating sensorineural hearing loss are challenged by the delivery across
multiple tissue barriers to the hard-to-access anatomical location of the inner ear. In this …

Cochlear hair cells are mechanoreceptors of the auditory system and cannot spontaneously
regenerate in adult mammals; thus hearing loss due to hair cell damage is permanent. In …

The loss of auditory sensory hair cells (HCs) is the most common cause of sensorineural
hearing loss (SNHL). As the main sound transmission structure in the cochlea, it is …

Merkel cell carcinoma (MCC) is an aggressive skin cancer frequently caused by the Merkel
cell polyomavirus (MCPyV). It is still under discussion, in which cells viral integration and …

Mammalian inner ear hair cells do not have the ability to spontaneously regenerate, so their
irreversible damage is the main cause of sensorineural hearing loss. The damage and loss …

In cis-regulatory elements, enhancers and promoters with complex molecular interactions
are used to coordinate gene transcription through physical proximity and chemical …

With increasing age, there is a notable increase in the differentiation of bone marrow-
derived mononuclear cells (BMMs) into osteoclasts, accompanied by a concurrent rise in …

Hearing loss is a significant disability that often goes under recognised, largely due to poor
identification, prevention, and treatment. Steps are being made to amend these pitfalls in the …

Aging causes progressive degenerative changes in many organs, particularly the auditory
system. Several attempts have been conducted to investigate preventive and therapeutic …

Recent advances of therapeutics for blast-induced hearing loss, based on their pathologies,
have been outlined. There are several promising therapeutic approaches for both middle …