Despite the remarkable advances in cancer diagnosis, treatment, and management over the
past decade, malignant tumors remain a major public health problem. Further progress in …

Molecular heterogeneity characterizes tumours' evolution and adaptation and, because of its
dynamics and continuous changes under external pressure, it is one of the major causes of …

Encouraging advances are being made in cancer immunotherapy modeling, especially in
the key areas of developing personalized treatment strategies based on individual patient …

Cancer is still one of the major causes of death worldwide. Even if its comprehension is
improving continuously, the complexity and heterogeneity of this group of diseases …

For an increasing number of preclinical samples, both detailed molecular profiles and their
responses to various drugs are becoming available. Efforts to understand, and predict, drug …

While tumor dynamic modeling has been widely applied to support the development of
oncology drugs, there remains a need to increase predictivity, enable personalized therapy …

Cancer is a complex disease, responsible for a significant portion of global deaths. The
increasing prioritisation of know-why over know-how approaches in biological research has …

Advances in melanoma treatments over the past decade have changed the course of
survival for patients. Several adjuvant therapies have been approved and are now …

Prostate cancer can be lethal in advanced stages, for which chemotherapy may become the
only viable therapeutic option. While there is no clear clinical management strategy fitting all …

Colorectal cancer (CRC) poses a significant global public health challenge as its prevalence
continues to increase. This study delves into the intricate dynamics of metastatic CRC by …