Mechanisms of Immune Evasion and Bone Tissue Colonization That Make Staphylococcus aureus the Primary Pathogen in Osteomyelitis

G Muthukrishnan, EA Masters, JL Daiss… - Current osteoporosis …, 2019 - Springer
Abstract Purpose of Review Staphylococcus aureus is the primary pathogen responsible for
osteomyelitis, which remains a major healthcare burden. To understand its dominance, here …

Neutrophil-Mediated Phagocytosis of Staphylococcus aureus

KPM van Kessel, J Bestebroer… - Frontiers in …, 2014 - frontiersin.org
Initial elimination of invading Staphylococcus aureus from the body is mediated by
professional phagocytes. The neutrophil is the major phagocyte of the innate immunity and …

Orthopaedic device-related infection: current and future interventions for improved prevention and treatment

TF Moriarty, R Kuehl, T Coenye… - EFORT open …, 2016 - eor.bioscientifica.com
Orthopaedic and trauma device-related infection (ODRI) remains one of the major
complications in modern trauma and orthopaedic surgery. Despite best practice in medical …

Staphylococci evade the innate immune response by disarming neutrophils and forming biofilms

L de Vor, SHM Rooijakkers, JAG van Strijp - FEBS letters, 2020 - Wiley Online Library
Staphylococcus aureus and Staphylococcus epidermidis can cause many types of
infections, ranging from skin infections to implant‐associated infections. The primary innate …

Nutrient Limitation Governs Staphylococcus aureus Metabolism and Niche Adaptation in the Human Nose

B Krismer, M Liebeke, D Janek, M Nega… - PLoS …, 2014 - journals.plos.org
Colonization of the human nose by Staphylococcus aureus in one-third of the population
represents a major risk factor for invasive infections. The basis for adaptation of S. aureus to …

Memory Th1 Cells Are Protective in Invasive Staphylococcus aureus Infection

AF Brown, AG Murphy, SJ Lalor, JM Leech… - PLoS …, 2015 - journals.plos.org
Mechanisms of protective immunity to Staphylococcus aureus infection in humans remain
elusive. While the importance of cellular immunity has been shown in mice, T cell responses …

Investigational drugs to treat methicillin-resistant Staphylococcus aureus

C Vuong, AJ Yeh, GYC Cheung… - Expert opinion on …, 2016 - Taylor & Francis
Introduction: Staphylococcus aureus remains one of the leading causes of morbidity and
mortality worldwide. This is to a large extent due to antibiotic-resistant strains, in particular …

Fighting Staphylococcus aureus biofilms with monoclonal antibodies

D Raafat, M Otto, K Reppschläger, J Iqbal… - Trends in …, 2019 - cell.com
Staphylococcus aureus (S. aureus) is a notorious pathogen and one of the most frequent
causes of biofilm-related infections. The treatment of S. aureus biofilms is hampered by the …

Staphylococcus aureus and Host Immunity in Recurrent Furunculosis

D Nowicka, E Grywalska - Dermatology, 2019 - karger.com
Staphylococcus aureus is one of the severest and most persistent bacterial pathogens. The
most frequent S. aureus infections include impetigo, folliculitis, furuncles, furunculosis …

Staphylococcal adaptation to diverse physiologic niches: an overview of transcriptomic and phenotypic changes in different biological environments

SS Dastgheyb, M Otto - Future microbiology, 2015 - Taylor & Francis
Host niches can differ strongly regarding, for example, oxygen tension, pH or nutrient
availability. Staphylococcus aureus and other staphylococci are common colonizers of …