Cannabis has been employed medicinally throughout history, but its recent legal prohibition,
biochemical complexity and variability, quality control issues, previous dearth of …

Recently, numerous side effects of synthetic drugs have lead to using medicinal plants as a
reliable source of new therapy. Pain is a global public health problem with a high impact on …

Background Comprehensive literature reviews of historical perspectives and evidence
supporting cannabis/cannabinoids in the treatment of pain, including migraine and …

The golden age of cannabis pharmacology began in the 1960s as Raphael Mechoulam and
his colleagues in Israel isolated and synthesized cannabidiol, tetrahydrocannabinol, and …

Plants produce a wide diversity of secondary metabolites (SM) which serve them as defense
compounds against herbivores, and other plants and microbes, but also as signal …

Tetrahydrocannabinol (THC) has been the primary focus of cannabis research since 1964,
when Raphael Mechoulam isolated and synthesized it. More recently, the synergistic …

Cannabis is a complex plant, with major compounds such as delta-9-tetrahydrocannabinol
and cannabidiol, which have opposing effects. The discovery of its compounds has led to …

Background Medicinal cannabis registries typically report pain as the most common reason
for use. It would be clinically useful to identify patterns of cannabis treatment in migraine and …

Medicine continues to struggle in its approaches to numerous common subjective pain
syndromes that lack objective signs and remain treatment resistant. Foremost among these …

Cannabis sativa L. is possibly one of the oldest plants cultivated by man, but has remained a
source of controversy throughout its history. Whether pariah or panacea, this most versatile …