Self-micro emulsifying formulation improved intestinal absorption and oral bioavailability of bakuchiol

J Pi, X Gao, Y Yu, Y Zheng, Z Zhu, Y Wang - Archives of pharmacal …, 2014 - Springer
Bakuchiol (BAK), isolated from the seeds of Psoralea corylifolia L., recently presents a
variety of pharmacologic activities. However, the poor oral bioavailability limits its further …

[图书][B] Inter subject variability in oral drug absorption

SC Rabbie - 2015 - search.proquest.com
A low and highly variable bioavailability is often the main reason for the failure of the
development of a drug intended for oral delivery. Focusing on absorption instead of …

Self-assembly of PEG-oligonucleotide-based matrices and lipoplexes as DNase-responsive delivery systems

WC Hung, JY Cherng - Polymer, 2015 - Elsevier
This study proposes a new concept of DNase-triggered delivery systems using polyethylene
glycol (PEG)-ssDNA matrices. To construct the matrices, firstly PEG molecules (4 k or 10 k or …

[图书][B] Salt solid dispersions: a formulation strategy to enhance dissolution rate of poorly water-soluble ionic drugs

AA Ghosh - 2012 - search.proquest.com
Improving oral bioavailability of poorly water-soluble drugs remains one of the most
challenging aspects of drug development. Pharmaceutical salt formation is a widely …

Study of formation self-nanoemulsifying systems, containing cationic peptide derivatives

OO Koloskova, AM Sumina, KI Kononova… - …, 2012 - elibrary.ru
Studies on production and properties of cationic submicron emulsions o/w, containing
lipopeptides as delivery systems for biologically active substances were carried out. In the …

[PDF][PDF] Application of lipocalin-type prostaglandin D synthase (L-PGDS) as a novel solubilizer for solid oral dosage forms

溝口雅之 - 2016 - omu.repo.nii.ac.jp
According to the recent approach shift for drug discovery from the phenotypic to target-based
approach, only the efficacy of candidate is focused and the candidate proceeding to the next …