Myeloid-derived suppressor cells as immunosuppressive regulators and therapeutic targets in cancer
K Li, H Shi, B Zhang, X Ou, Q Ma, Y Chen… - Signal transduction and …, 2021 - nature.com
Myeloid-derived suppressor cells (MDSCs) are a heterogenic population of immature
myeloid cells with immunosuppressive effects, which undergo massive expansion during …
myeloid cells with immunosuppressive effects, which undergo massive expansion during …
Myeloid-derived suppressor cells coming of age
Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of cells
generated during a large array of pathologic conditions ranging from cancer to obesity …
generated during a large array of pathologic conditions ranging from cancer to obesity …
Monocytes in the tumor microenvironment
S Ugel, S Canè, F De Sanctis… - Annual Review of …, 2021 - annualreviews.org
Immunotherapy has revolutionized cancer treatment over the past decade. Nonetheless,
prolonged survival is limited to relatively few patients. Cancers enforce a multifaceted …
prolonged survival is limited to relatively few patients. Cancers enforce a multifaceted …
Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards
Myeloid-derived suppressor cells (MDSCs) have emerged as major regulators of immune
responses in cancer and other pathological conditions. In recent years, ample evidence …
responses in cancer and other pathological conditions. In recent years, ample evidence …
Macrophage polarization
PJ Murray - Annual review of physiology, 2017 - annualreviews.org
Macrophage polarization refers to how macrophages have been activated at a given point in
space and time. Polarization is not fixed, as macrophages are sufficiently plastic to integrate …
space and time. Polarization is not fixed, as macrophages are sufficiently plastic to integrate …
Myeloid-derived suppressor cells: a propitious road to clinic
A Grover, E Sanseviero, E Timosenko, DI Gabrilovich - Cancer discovery, 2021 - AACR
Myeloid-derived suppressor cells (MDSC) are important regulators of immune responses in
cancer. They represent a relatively stable form of pathologic activation of neutrophils and …
cancer. They represent a relatively stable form of pathologic activation of neutrophils and …
The nature of myeloid-derived suppressor cells in the tumor microenvironment
V Kumar, S Patel, E Tcyganov, DI Gabrilovich - Trends in immunology, 2016 - cell.com
Myeloid-derived suppressor cells (MDSC) are one of the major components of the tumor
microenvironment. The main feature of these cells is their potent immune suppressive …
microenvironment. The main feature of these cells is their potent immune suppressive …
Immunology in the liver—from homeostasis to disease
The liver is a central immunological organ with a high exposure to circulating antigens and
endotoxins from the gut microbiota, particularly enriched for innate immune cells …
endotoxins from the gut microbiota, particularly enriched for innate immune cells …
An innate IL-25–ILC2–MDSC axis creates a cancer-permissive microenvironment for Apc mutation–driven intestinal tumorigenesis
E Jou, N Rodriguez-Rodriguez, ACF Ferreira… - Science …, 2022 - science.org
Interleukin-25 (IL-25) and group 2 innate lymphoid cells (ILC2s) defend the host against
intestinal helminth infection and are associated with inappropriate allergic reactions. IL-33 …
intestinal helminth infection and are associated with inappropriate allergic reactions. IL-33 …
Myeloid-derived suppressor cells in the tumor microenvironment: expect the unexpected
D Marvel, DI Gabrilovich - The Journal of clinical …, 2015 - Am Soc Clin Investig
Our understanding of the role of myeloid-derived suppressor cells (MDSCs) in cancer is
becoming increasingly complex. In addition to their eponymous role in suppressing immune …
becoming increasingly complex. In addition to their eponymous role in suppressing immune …