Myeloid-derived suppressor cells as immunosuppressive regulators and therapeutic targets in cancer

K Li, H Shi, B Zhang, X Ou, Q Ma, Y Chen… - Signal transduction and …, 2021 - nature.com
Myeloid-derived suppressor cells (MDSCs) are a heterogenic population of immature
myeloid cells with immunosuppressive effects, which undergo massive expansion during …

Myeloid-derived suppressor cells coming of age

F Veglia, M Perego, D Gabrilovich - Nature immunology, 2018 - nature.com
Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of cells
generated during a large array of pathologic conditions ranging from cancer to obesity …

Monocytes in the tumor microenvironment

S Ugel, S Canè, F De Sanctis… - Annual Review of …, 2021 - annualreviews.org
Immunotherapy has revolutionized cancer treatment over the past decade. Nonetheless,
prolonged survival is limited to relatively few patients. Cancers enforce a multifaceted …

Myeloid-derived suppressor cells: a propitious road to clinic

A Grover, E Sanseviero, E Timosenko, DI Gabrilovich - Cancer discovery, 2021 - AACR
Myeloid-derived suppressor cells (MDSC) are important regulators of immune responses in
cancer. They represent a relatively stable form of pathologic activation of neutrophils and …

Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards

V Bronte, S Brandau, SH Chen, MP Colombo… - Nature …, 2016 - nature.com
Myeloid-derived suppressor cells (MDSCs) have emerged as major regulators of immune
responses in cancer and other pathological conditions. In recent years, ample evidence …

Macrophage polarization

PJ Murray - Annual review of physiology, 2017 - annualreviews.org
Macrophage polarization refers to how macrophages have been activated at a given point in
space and time. Polarization is not fixed, as macrophages are sufficiently plastic to integrate …

The nature of myeloid-derived suppressor cells in the tumor microenvironment

V Kumar, S Patel, E Tcyganov, DI Gabrilovich - Trends in immunology, 2016 - cell.com
Myeloid-derived suppressor cells (MDSC) are one of the major components of the tumor
microenvironment. The main feature of these cells is their potent immune suppressive …

Immunology in the liver—from homeostasis to disease

F Heymann, F Tacke - Nature reviews Gastroenterology & hepatology, 2016 - nature.com
The liver is a central immunological organ with a high exposure to circulating antigens and
endotoxins from the gut microbiota, particularly enriched for innate immune cells …

Cancer stem cells: advances in knowledge and implications for cancer therapy

X Chu, W Tian, J Ning, G Xiao, Y Zhou… - … and Targeted Therapy, 2024 - nature.com
Cancer stem cells (CSCs), a small subset of cells in tumors that are characterized by self-
renewal and continuous proliferation, lead to tumorigenesis, metastasis, and maintain tumor …

Myeloid-derived suppressor cells in the tumor microenvironment: expect the unexpected

D Marvel, DI Gabrilovich - The Journal of clinical …, 2015 - Am Soc Clin Investig
Our understanding of the role of myeloid-derived suppressor cells (MDSCs) in cancer is
becoming increasingly complex. In addition to their eponymous role in suppressing immune …