Wnt signaling executes an indispensable performance in osteoblast differentiation, bone
development, homeostasis, and remodeling. Wnt signals trigger the intracellular Wnt …

Multiple myeloma (MM) is a plasma cell malignancy with a significant heritable basis.
Genome-wide association studies have transformed our understanding of MM …

Hand grip strength is a widely used proxy of muscular fitness, a marker of frailty, and
predictor of a range of morbidities and all-cause mortality. To investigate the genetic …

Glaucoma is a leading cause of irreversible blindness worldwide. Primary open-angle
glaucoma (POAG), the most common type, is a complex inherited disorder that is …

Vitamin D insufficiency is common, correctable, and influenced by genetic factors, and it has
been associated with risk of several diseases. We sought to identify low-frequency genetic …

Osteoporosis is a devastating disease with an essential genetic component. GWAS have
discovered genetic signals robustly associated with bone mineral density (BMD), but not the …

Sulfation is a widespread modification of biomolecules that has been incompletely explored
to date. Through cross-phenotype meta-analysis of bone mineral density in up to 426,824 …

Background With the advancement of world population aging, age-related osteoporosis
(OP) and sarcopenia (SP) impose enormous clinical and economic burden on society …

Background Since screening programs identify only a small proportion of the population as
eligible for an intervention, genomic prediction of heritable risk factors could decrease the …

Skull bone mineral density (SK-BMD) provides a suitable trait for the discovery of key genes
in bone biology, particularly to intramembranous ossification, not captured at other skeletal …