Betulinic acid as apoptosis activator: Molecular mechanisms, mathematical modeling and chemical modifications

P Kumar, AS Bhadauria, AK Singh, S Saha - Life sciences, 2018 - Elsevier
A natural product betulinic acid (BA) has gained a huge significance in the recent years for
its strong cytotoxicity. Surprisingly, in spite of being an interesting cancer protecting agent on …

[HTML][HTML] Immunomodulatory effects and structure-activity relationship of botanical pentacyclic triterpenes: A review

NH Harun, AW Septama, WANW Ahmad… - Chinese Herbal …, 2020 - Elsevier
Botanical pentacyclic triterpenes possessed a broad range of pharmacological activities
such as anti-oxidant, anti-tumor, anti-microbial and anti-inflammatory activities. It is believed …

[HTML][HTML] In vitro evaluation of anticancer potentials of lupeol isolated from Elephantopus scaber L. on MCF-7 cell line

D Pitchai, A Roy, C Ignatius - Journal of advanced pharmaceutical …, 2014 - journals.lww.com
Lupeol is a triterpenoid, present in most of the medicinally effective plants and possess a
wide range of biological activity against human diseases. The present study aims at …

High value triterpenic compounds from the outer barks of several Eucalyptus species cultivated in Brazil and in Portugal

RMA Domingues, GDA Sousa, CM Silva… - Industrial Crops and …, 2011 - Elsevier
The chemical composition of the lipophilic extracts of the inner and outer bark fractions of
Eucalyptus grandis and Eucalyptus urograndis (E. grandis× Eucalyptus urophylla) cultivated …

[HTML][HTML] The wound healing properties of betulin from birch bark from bench to bedside

A Scheffler - Planta medica, 2019 - thieme-connect.com
With central European approval in January 2016 for a betulin-oleogel (Episalvan), used to
accelerate wound closure in partial thickness wounds, the herbal active ingredient triterpene …

A bioguided identification of the active compounds that contribute to the antiproliferative/cytotoxic effects of rosemary extract on colon cancer cells

I Borrás-Linares, A Pérez-Sánchez… - Food and Chemical …, 2015 - Elsevier
Rosemary extracts have exhibited potential cytostatic or cytotoxic effects in several cancer
cell models but their bioactive compounds are yet to be discovered. In this work, the …

[HTML][HTML] EGFR-targeted pentacyclic triterpene analogues for glioma therapy

HI Ciftci, MO Radwan, B Sever, AK Hamdy… - International Journal of …, 2021 - mdpi.com
Glioma, particularly its most malignant form, glioblastoma multiforme (GBM), is the most
common and aggressive malignant central nervous system tumor. The drawbacks of the …

[HTML][HTML] Application of UHPLC-ESI-QTOF-MS in phytochemical profiling of sage (Salvia officinalis) and rosemary (Rosmarinus officinalis)

R Velamuri, Y Sharma, J Fagan… - Planta Medica …, 2020 - thieme-connect.com
UHPLC with QTOF-MS is widely used as a powerful tool for metabolomic analysis. This
technology has recently been applied to the analysis of polyphenols in food and herb …

Anti-angiogenic and anti-cancer evaluation of betulin nanoemulsion in chicken chorioallantoic membrane and skin carcinoma in Balb/c mice

CA Dehelean, S Feflea, D Gheorgheosu… - Journal of …, 2013 - ingentaconnect.com
Betulin (Bet), the main component of birch tree bark, has been recently reported to exert
anticancer activity in several cell lines; however the underlying mechanisms are only …

Biosynthesis of structurally diverse triterpenes in plants: the role of oxidosqualene cyclases

S Ghosh - 2016 - insajournal.in
Triterpenes, thirty-carbon compounds derived from five-carbon isoprene units, are among
the largest and diverse classes of natural products. To date, over 20,000 distinct triterpene …