Therapeutic strategy of mesenchymal-stem-cell-derived extracellular vesicles as regenerative medicine

Y Matsuzaka, R Yashiro - International Journal of Molecular Sciences, 2022 - mdpi.com
Extracellular vesicles (EVs) are lipid bilayer membrane particles that play critical roles in
intracellular communication through EV-encapsulated informative content, including …

Engineered EVs designed to target diseases of the CNS

L Nieland, S Mahjoum, E Grandell, K Breyne… - Journal of Controlled …, 2023 - Elsevier
Diseases of the central nervous system (CNS) are challenging to treat, mainly due to the
blood-brain barrier (BBB), which restricts drugs in circulation from entering target regions in …

Advances and perspectives in dental pulp stem cell based neuroregeneration therapies

J Luzuriaga, Y Polo, O Pastor-Alonso… - International journal of …, 2021 - mdpi.com
Human dental pulp stem cells (hDPSCs) are some of the most promising stem cell types for
regenerative therapies given their ability to grow in the absence of serum and their realistic …

Huntingtin co-isolates with small extracellular vesicles from blood plasma of TgHD and KI-HD pig models of Huntington's disease and human blood plasma

H Ananbeh, J Novak, S Juhas, J Juhasova… - International journal of …, 2022 - mdpi.com
(1) Background: Huntington's disease (HD) is rare incurable hereditary neurodegenerative
disorder caused by CAG repeat expansion in the gene coding for the protein huntingtin …

A new perspective on depression and neuroinflammation: Non-coding RNA

S Zhou, R Chen, Y She, X Liu, H Zhao, C Li… - Journal of psychiatric …, 2022 - Elsevier
The high incidence and relapse rate of depression, as well comorbidity with other diseases,
has made depression one of the primary causes of years of life lived with disability …

Insertion of the Icelandic mutation (A673T) by prime editing: a potential preventive treatment for familial and sporadic Alzheimer's disease

G Tremblay, J Rousseau, CH Mbakam… - The CRISPR …, 2022 - liebertpub.com
Alzheimer's disease (AD) is the result of abnormal processing of the amyloid precursor
protein (APP) by β-secretase and γ-secretase, which leads to the formation of toxic β …

Neuroprotective and neurotoxic effects of glial-derived exosomes

K Oyarce, MY Cepeda, R Lagos, C Garrido… - Frontiers in cellular …, 2022 - frontiersin.org
Exosomes derived from glial cells such as astrocytes, microglia, and oligodendrocytes can
modulate cell communication in the brain and exert protective or neurotoxic effects on …

Toward a human brain extracellular vesicle atlas: Characteristics of extracellular vesicles from different brain regions, including small RNA and protein profiles

Y Huang, T Arab, AE Russell, ER Mallick… - Interdisciplinary …, 2023 - Wiley Online Library
Extracellular vesicles (EVs) are released from different cell types in the central nervous
system (CNS) and play roles in regulating physiological and pathological functions …

Long non-coding RNAs, extracellular vesicles and inflammation in Alzheimer's disease

A Canseco-Rodriguez, V Masola, V Aliperti… - International Journal of …, 2022 - mdpi.com
Alzheimer's Disease (AD) has currently no effective treatment; however, preventive
measures have the potential to reduce AD risk. Thus, accurate and early prediction of risk is …

Exosome-based delivery nanoplatforms: next-generation theranostic platforms for breast cancer

Y Zheng, M Li, B Weng, H Mao, J Zhao - Biomaterials Science, 2022 - pubs.rsc.org
Breast cancer is the most frequent type of malignancy, and the leading cause of cancer-
related death in women across the globe. Exosomes are naturally derived 50–150 nm …