111. PHYSIOLOGICAL REGULATION OF ODC BY HORMONES AND SECOND
MESSENGERS.............. A. Polypeptide and Amine Trophic Hormones........ B. Steroid …

Publisher Summary This chapter highlights the regulation and function of ornithine
decarboxylase (ODC) and of the polyamines. ODC catalyzes the synthesis of putrescine. It is …

Inhibition of cardiac ornithine decarboxylase (ODC) by α-difluoromethylornithine (DFMO) did
not prevent normal cardiac growth in mature rats but attenuated isoproterenol-induced …

It appears that the induction of ornithine decarboxylase regulates the rate of ribosomal RNA
synthesis as well as regulating the rate of synthesis of polyamines. Further, ornithine …

Putrescine, spermidine, and spermine, as well as other primary amine substances, when
added exogenously to growth-stimulated systems, inhibit ornithine decarboxylase (ODC) …

Chronic continuous infusion of norepinephrine (NE) or epinephrine (Epi) subcutaneously in
rats resulted in a rapid elevation of systolic blood pressure (SBP) by 40 mm Hg. Pressure …

The aliphatic amines putrescine, spermidine and spermine are natural polycations widely
distributed in prokariotic and eukariotic ceils. Although they have been known for over 300 …

Sympathetic stimulation elevates heart ornithine decarboxylase (ODC) activity in adult rats,
an effect which is followed by cardiac hypertrophy. In developing animals, adrenergic …

In three models of cardiac hypertrophy the significance of catecholamines and the adenylate
cyclasecyclic AMP-system was examined. Two approaches were utilized: I. The time course …

(1) Ornithine decarboxylase induction in response to a variety of trophic stimuli, including
trophic hormones, appears to occur via a transcriptional mechanism mediated by the …